SIRT1 transgenic mice show phenotypes resembling calorie restriction

By Laura Bordone, Dena E. Cohen, Ashley S. Robinson, Maria Carla Motta, Ed van Veen, A. Czopik, Andrew D. Steele, Hayley Crowe, S. Marmor, Jianyuan Luo and 2 more. Aging Cell, 2007

743 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/3f819fe5c272f917e3fe4391425cd912cb2d8633

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. Johan Auwerx
4. M. Haigis
5. R. Houtkooper
6. Joseph A. Baur
7. S. Imai
8. T. Nakagawa

In Physiology

1. D. Sinclair
2. L. Guarente
3. Johan Auwerx
4. M. Haigis
5. R. Houtkooper
6. Joseph A. Baur
7. S. Imai
8. T. Nakagawa

Citations in the corpus

• Caloric restriction. (2011, methodology): “This is because the original in vitro assay used to show its activation of SIRT1 involves a flouophore, but when the fluophore is absent the activation disappears (Kaeberlein et al., 2005; Borra et al., 2005).”
• Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “Uncoupling protein 2 (UCP-2) expression is induced by AICAR (Jager et al., 2007) and is repressed by SIRT1 in basal conditions (Bordone et al., 2007) (Moynihan et al., 2005).”
• Sirtuins as regulators of metabolism and healthspan (2012, background): “This hypothesis is based on observed metabolic changes (lowered fasting glucose levels and/or hepatic glucose production) in SIRT1 transgenic mic”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “However, most studies show compelling evidence that SIRT1 overexpression offers substantial benefits on serum cholesterol and insulin levels and increased resistance to high-fat diet induced glucose intolerance and insulin resistance (28, 46, 249).”
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “…of SIRT1 mimics many of the salutary effects of CR, including a reduced incidence of cardiovascular and metabolic diseases (Banks et al., 2008; Bordone et al., 2007; Pfluger et al., 2008), cancer (Herranz et al., 2010; Oberdoerffer et al., 2008), and neurodegeneration (Donmez et al., 2010;…”
• Resveratrol and health--a comprehensive review of human clinical trials. (2011, background): “Intriguingly, some of the beneficial effects of resveratrol appear to be replicated by overexpression of SIRT1 [16], or by treatment with a structurally unrelated SIRT1 activator [17], and animals that lack AMPK fail to exhibit many of the normal responses to resveratrol [18].”
• Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. (2013, background): “, 2010), Sirt1-overexpressing transgenic mice display phenotypes similar to DR mice (Bordone et al., 2007) or preventive effects on metabolic complications caused by high-fat diet and aging (Banks et al.”
• A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “Given that overexpression of SIRT1 in mice does induce physiological alterations consistent with CR [32], it is possible that CR impacts the levels of SIRT1 and other sirtuins in other tissues that play a central role in regulating metabolism, such the pancreas [33,34].”
• SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009, positive): “In mammals, genetic alterations in SIRT1 can affect at least some of the phenotypes associated with calorie restriction (Bordone et al., 2007; Chen et al., 2005).”
• Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, positive): “, 2004), overexpression of Sirt1, the mammalian homolog of Sir2, has been reported to protect mice from aging-related phenotypes that are similar to type 2 diabetes (Banks et al., 2008; Bordone et al., 2007; Pfluger et al., 2008), cancer (Herranz et al.”
• Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “…al., 1999), worms (Tissenbaum and Guarente, 2001), and flies (Rogina and Helfand, 2004), and are proposed to underlie some of the physiological effects of DR in simple organisms (Anderson et al., 2003; Lin et al., 2000) and in mammals (Boily et al., 2008; Bordone et al., 2007; Chen et al., 2005).”
• Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-related Hearing Loss under Caloric Restriction (2010, background): “Previous studies have focused on the role of Sirt1 as the major sirtuin mediating the metabolic effects of CR in mammals (Chen et al., 2005; Bordone et al., 2007; Chen et al., 2008).”
• SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice (2008, neutral): “In SirT1 knockin mice (Bordone et al., 2007), the transgene is expressed off the b-actin locus, leading potentially to developmental effects that impair adipocyte differentiation (Picard et al.”