NAD+ in Brain Aging and Neurodegenerative Disorders.

By Sofie Lautrup, D. Sinclair, Mark P. Mattson, Evandro Fei Fang. Cell Metabolism, 2019

660 citations recorded by the source corpus.

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

Subfields: Biological Psychiatry, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/25929e3182d6bc1c88272028a9c06bfb4a534745

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Citations in the corpus

• Hallmarks of neurodegenerative diseases. (2023, neutral): “221”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “In contrast to the neuroprotection role of SIRT1, SIRT2 upregulation is toxic to neuronal cells.540,557,560–564 A preliminary clinical trial has confirmed the importance of SIRT1 activation and NAD+ metabolism in ALS.”