S. Imai

Geriatrics and Gerontology · 2000–2017

A researcher in the Science corpus: 12 papers; trusts 17 researchers and is trusted by 22 researchers here, as inferred from the citation graph.

Subfields

• Geriatrics and Gerontology — 96 citations into it; #5 of 114 by trust here, #3 by citations
• Physiology — 75 citations into it; #621 of 2,276 by trust here, #421 by citations
• Aging — 51 citations into it; #61 of 261 by trust here, #33 by citations
• Molecular Biology — 40 citations into it; #4,596 of 17,773 by trust here, #1,795 by citations
• Epidemiology — 22 citations into it; #525 of 2,148 by trust here, #945 by citations
• Oncology — 15 citations into it; #220 of 1,698 by trust here, #236 by citations

Whom S. Imai trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. Jun Yoshino
2. C. Cantó
3. Su-Ju Lin
4. L. Guarente
5. K. Mills
6. Kevin J. Bitterman
7. Javier R. Revollo
8. Rozalyn M. Anderson

Who trusts S. Imai overall

1. L. Guarente
2. E. Seto
3. E. Verdin
4. C. Cantó
5. Jun Yoshino
6. R. Houtkooper
7. K. Mills
8. M. Haigis
9. Maria Carla Motta
10. Douglas C. Wallace

Papers from S. Imai's perspective

Ordered by how strongly the researchers S. Imai trusts endorse each paper. Same corpus, a different order for every researcher.

1. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice (Cell Metabolism)
2. Mitonuclear protein imbalance as a conserved longevity mechanism (Nature)
3. Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila (Nature)
4. The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (Cell)
5. The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells* (Journal of Biological Chemistry)
6. Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis (Science)
7. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (Developmental Cell)
8. Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (PLoS ONE)
9. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle (Cell Metabolism)
10. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. (Proceedings of the National Academy of Sciences of the United States of America)

Their papers

• Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase (2000) — 3,482 citations
• hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. (2001) — 2,660 citations
• NAD+ intermediates: The biology and therapeutic potential of NMN and NR (2017) — 930 citations
• Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2016) — 803 citations
• NAD+ and Sirtuins in Aging and Disease (2014) — 1,326 citations
• Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. (2013) — 706 citations
• Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice (2011) — 1,291 citations
• Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis (2009) — 1,093 citations
• Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. (2007) — 947 citations
• Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. (2005) — 667 citations
• The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells* (2004) — 990 citations
• Negative control of p53 by Sir2alpha promotes cell survival under stress. (2001) — 1,098 citations