Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

By K. Howitz, Kevin J. Bitterman, H. Cohen, Dudley Lamming, Siva Lavu, Jason G. Wood, R. Zipkin, Phuong Chung, A. Kisielewski, Li-li Zhang and 2 more. Nature, 2003

3,808 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/0abae9d776e805acdb64d6b7603fe045fba3bd57

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. D. Sinclair
3. V. Longo
4. M. Haigis
5. Brian K. Kennedy
6. Johan Auwerx
7. J. Kirkland
8. C. Cantó

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. L. Guarente
4. C. Cantó
5. Bor Luen Tang
6. M. Haigis
7. R. Houtkooper
8. Joseph A. Baur

In Pathology and Forensic Medicine

1. D. Hardie
2. C. A. de la Lastra
3. I. Villegas
4. Barry Halliwell
5. Peter A. Jones
6. S. Baylin
7. Michael R Hamblin

Citations in the corpus

• SIRT1 and other sirtuins in Metabolism (2013, background): “In addition, SIRT1 activators like resveratrol [44] and newer sirtuin activating compounds (STACs) [45], exert effects that are similar to those of CR as revealed by measures of whole animal physiology [46] or by transcriptional profiling [47].”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Initial screening studies identified the polyphenol resveratrol as a potent activator of SIRT1 (141).”
• Epigenetics and aging (2016, background): “Although resveratrol stimulates Sir2/SIRT1 activity in vitro (209), its stimulatory interaction with SIRT1 depended on binding to the 7-amino-4-methylcoumarin (AMC) fluorophore within the histone peptide substrate used to measure deacetylase activity (210).”
• Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice (2008, positive): “To test this, we investigated whether this Sirt1 allele is functional by using resveratrol, an activator of SIRT1 (Howitz et al., 2003).”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “Supporting this hypothesis, several studies indicated that Sir2 could be a critical mediator of the beneficial effects of calorie restriction (CR) on yeast life span (61, 62).”
• Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? (2005, background): “Second, flavonoids and other phenols are complex molecules and are likely to have multiple potential biological activities, such as inhibiting telomerase (30), affecting signal transduction pathways (31–33), inhibiting cyclooxygenases and lipoxygenases (34–36), decreasing xanthine oxidase (37), matr”
• Flavonoids as developmental regulators. (2005, background): “For example, flavonoids have estrogenic activity [48], inhibit protein-tyrosine kinase activity [49,50], and function as allosteric activators of the sirtuin deacetylases (NAD-dependent deacetylases) that regulate caloricrestricted longevity in yeast, worms, flies and in human cells [51 ,52,53].”
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “Sir2 exerts its effects on transcriptional and recombinational silencing via modulation of chromatin structure (Fritze et al., 1997) by catalyzing NAD-dependent deacetylation of histones (Imai et al., 2000; Smith et al., 2000).”
• AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009, background): “Resveratrol, which was discovered in a small-molecule screen to be a Sirt1 activator (1), has drawn a great deal of interest for its therapeutic potential in treating metabolic disorders such as type 2 diabetes.”