Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

By B. Rogina, S. Helfand. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,388 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Geriatrics and Gerontology

View Paper: https://www.semanticscholar.org/paper/5c9d55c62ea828e2d6851f0522453c26906d0f8d

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In Aging

1. D. Sinclair
2. L. Guarente
3. V. Longo
4. M. Haigis
5. Brian K. Kennedy
6. Johan Auwerx
7. F. Picard
8. E. Verdin

In Cellular and Molecular Neuroscience

1. Guillermo Mariño
2. D. Sinclair
3. E. Verdin
4. T. Nyström
5. Guido Kroemer
6. Johan Auwerx
7. L. Guarente
8. V. Longo

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. L. Guarente
4. Bor Luen Tang
5. C. Cantó
6. E. Verdin
7. M. Haigis
8. R. Houtkooper

Citations in the corpus

• Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. (2010, background): “In the budding yeast Saccharomyces cerevisiae and the fruit fly Drosophila melanogaster, CR extends life span by increasing the activity of the Sir2 protein (Lin et al., 2000; Rogina and Helfand, 2004).”
• Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “, 1999), worms (Tissenbaum and Guarente, 2001), and flies (Rogina and Helfand, 2004), and are proposed to underlie some of the physiological effects of DR in simple organisms (Anderson et al.”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “Different nuclear sirtuin orthologs have been shown to influence lifespan in yeast, worms, flies, and mice (Bauer et al., 2009; Boily et al., 2008; Kaeberlein et al., 1999; Kanfi et al., 2012; Rogina and Helfand, 2004; Tissenbaum and Guarente, 2001).”
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005, result): “Our data present a striking contrast to the lifespan extension in lower eukaryotes by Sir2 and its homologues (Kaeberlein et al., 1999; Tissenbaum and Guarente, 2001; Rogina and Helfand, 2004) and suggest complex layers of regulation of replicative aging in human cells.”
• Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “Resveratrol was chosen for study because of promising data (25) from animal models of cancer, heart disease, stroke, and immunity and because of data suggesting it could activate sirtuins, a class of protein deacetylases implicated in control of life span in yeast (26), flies (27), and worms (28).”
• SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007, background): “Mutation of Sir2 or blocking of NAD synthesis abolishes the effect of caloric restriction in yeast (Lin et al ., 2000) or flies (Rogina & Helfand, 2004).”
• Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007, background): “Genetic evidence for a role of Sir2 in this nutrient/aging pathway has been provided in model organisms such as yeast (Kaeberlein et al, 1999), worms (Tissenbaum and Guarente, 2001) and flies (Rogina and Helfand, 2004).”
• SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress (2010, background): “The sirtuin genes are also central to the regulation of longevity in C. elegans and D. melanogaster ( Rogina and Helfand, 2004 ).”