Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

By A. Brunet, Lora B. Sweeney, J. Sturgill, Katrin F. Chua, Paul L. Greer, Yingxi Lin, Hien G. Tran, S. E. Ross, R. Mostoslavsky, H. Cohen and 7 more. Science, 2004

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle (2010, background): “The activities of PGC-1a (Rodgers et al., 2005) and FOXOs (Brunet et al., 2004) are critically influenced by the control of their acetylation levels through the type III NAD+-dependent deacetylase SIRT1.”
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK (2004, background): “Both negative (Brunet et al, 2004; van der Horst et al, 2004) and positive (Motta et al, 2004) regulations of FOXO transcriptional activity by acetylation have been reported.”
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005, neutral): “2”
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007, methodology): “We do not rule out the possibility that other known substrates of SIRT1 are involved, such as Ku70, a protein that sequesters the apoptotic protein Bax from mitochondria (Brunet et al, 2004; Cohen et al, 2004a).”
The Role of Sirtuins in Antioxidant and Redox Signaling (2017, background): “SIRT1 is known to deacetylate FOXO3a, which has been found to induce antioxidant responses via modulation in SOD2 and CAT (19, 55).”