The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
By S. Solon-Biet, A. Mcmahon, J. Ballard, K. Ruohonen, Lindsay E. Wu, V. Cogger, A. Warren, Xin Huang, N. Pichaud, Richard G Melvin and 8 more. Cell Metabolism, 2014
870 citations recorded by the source corpus.
Summary The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin (mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation.
Subfields: Aging, Physiology
View Paper: https://www.semanticscholar.org/paper/86f6a029382792cb48aab3e24d56e721ce7780dd
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Citations in the corpus
- Metabolic Control of Longevity. (2016, background): “Extensive studies on the links between macronutrients and lifespan in mice have confirmed that health and longevity are supported by the replacement of proteins with carbohydrates (Solon-Biet et al., 2014).”