Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging

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Ageing as a risk factor for disease. (2012, positive): “DNA Damage Response Pathway and Telomeres Both environmental factors, such as UV irradiation and the cell’s own metabolic processes (generating ROS) can lead to DNA damage, which tends to accumulate with time [75].”
DNA damage and its links to neurodegeneration (2014, positive): “…involves direct ligation of the broken DNA ends and is error prone, or homologous recombination (HR), which is selectively utilized in the S and G2 phases of the cell cycle and employs homologous sequences in the sister chromatid as a template to ensure error-free repair (Lombard et al., 2005).”
Oxidative Stress Resistance in Deinococcus radiodurans (2011, neutral): “radiodurans from oxidative stress is determined by protection against protein oxidation, researchers still argue whether aging and cancer are a consequence of the accumulation of DNA damage (371, 542) or protein damage (117, 353), as both genomic instability and the accumulation of protein damage ar”