Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

By T. Koshiba, Scott A. Detmer, Jens T. Kaiser, Hsiuchen Chen, J. McCaffery, D. C. Chan. Science, 2004

930 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fd8600cbb9cdb5274c61ece5aa1b8730d58ec5b5

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Citations in the corpus

Mitochondrial fusion and fission in cell life and death (2010, background): “Consistently, the carboxy-terminal heptad repeats of mammalian MFN1 have been shown to form an intermolecular antiparallel coiled coil that may tether adjacent mitochondria prior to fusio”
Mitochondrial dynamics and apoptosis. (2008, neutral): “The C-terminal coiled-coil region of Mfn1 and Mfn2 mediates tethering between mitochondria through homo- or heterotypic complexes formed between adjacent mitochondria (Chen et al. 2003; Ishihara et al. 2004; Koshiba et al. 2004; Meeusen et al. 2004).”
Mitochondrial fragmentation in neurodegeneration (2008, background): “In addition, MFN1 and MFN2 have been found to form homo-oligomeric and hetero-oligomeric complexes in trans”
Mitochondrial fusion and fission in mammals. (2006, background): “…membrane potential: the electrical gradient that is present across the mitochondrial inner membrane and that is generated by proton pumping by components of the respiratory chain Mfn1 HR2 forms a 95 Å, dimeric antiparallel coiled coil with transmembrane regions on either end (Koshiba et al. 2004).”
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (2008, background): “, 2003) and act in trans with similar complexes on opposing mitochondrial membranes during fusion (Koshiba et al., 2004; Meeusen et al., 2004).”
Mechanisms of mitochondrial fission and fusion. (2013, background): “Current models suggest that the fusion Dynamins from opposing membranes dimerize and then pull the membranes together with a SNARE-like mechanism (Koshiba et al. 2004).”
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin (2010, background): “Because Mitofusins mediate the tethering and fusion of mitochondria via homo- and heterotypic interaction of their HR2 domains (43), we hypothesize that Parkinmediated Mfn ubiquitination may interfere with intermolecular interactions preventing fusion.”
Functions and dysfunctions of mitochondrial dynamics (2007, background): “Mitofusins are required on adjacent mitochondria during the fusion process, implying that they form complexes in trans between apposing mitochondri”
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, neutral): “MFN2 is presumed to have mostly a regulatory role (Ishihara et al., 2004), while MFN1 tethers two juxtaposed organelles (Koshiba et al., 2004) and cooperates with Optic Atrophy 1 (OPA1) in the fusion process (Cipolat et al., 2004).”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, neutral): “MFN1 and 2 are located in the outer mitochondrial membrane and mediate outer membrane fusion by the formation of homo-and heterodimers that tether adjacent mitochondria (Koshiba et al , 2004).”