Mitochondrial fusion and fission in mammals.

By D. C. Chan. Annual Review of Cell and Developmental Biology, 2006

993 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5dabfdf316c6f8bdad21c106c2679a673c8ce920

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Citations in the corpus

Mitochondrial fragmentation in neurodegeneration (2008, background): “The current mitochondrial fusion hypothesis states that MFN2 and OPA1 are mechano-enzymes that use GTP hydrolysis to switch between distinct conformations that facilitate membrane fusio”
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice (2009, background): “Mitochondrial morphology changes dynamically as a result of a balance in the fusion and fission occurring in response to cellular energy demands, differentiation or pathological condition”
Mechanisms of membrane fusion: disparate players and common principles (2008, background): “Fusion and fission are essential for normal mitochondrial functio”
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (2008, background): “Mitochondrial fission facilitates the redistribution of mitochondria in response to local changes in the demand for ATP, whereas mitochondrial fusion is needed to exchange mitochondrial DNA and other components that may become damaged over time (Okamoto and Shaw, 2005; Chan, 2006).”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “Mitochondrial fusion dilutes dysfunctional proteins and mutated mtDNA by mixing mitochondrial proteins, mtDNA and other matrix components to maintain mitochondrial homogeneity and functional stability.(55) Genetic knockout of MFN1 and/or MFN2, destroys the mitochondrial structure and induces serious”
Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease (2009, background): “However, although OPA1/Mfn1/Mfn2 reduction or Fis1 overexpression could lead to mitochondrial fragmentation, DLP1 reduction could cause mitochondrial elongation and thus may make the net effect on mitochondrial morphology uncertain (Chan, 2006).”
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “The frequencies of fusion and fission events are balanced to maintain the overall morphology of the mitochondrial population (8, 41).”
Mitochondria in innate immune responses (2011, background): “Mitochondrial dynamics determine the integrity of the mitochondrial network and maintain respiratory capacity, but also participate in several other processes, including mammalian development, neurodegeneration and apoptosi”
Functions and dysfunctions of mitochondrial dynamics (2007, background): “Recent studies have led to renewed appreciation for the fact that the mitochondrial structure is highly dynami”
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “Specifically, mitochondrial fusion permits the exchange of mitochondrial contents, such as lipid membrane and mtDNA, such that the percentage of mitochondria containing defective components remains at a minimum [34,35].”
The role of mitochondria in apoptosis. (2008, background): “The mitochondrial reticulum can be rapidly remodeled by dynamic fission and fusion events in response to the physiological requirements of a cell (1, 66, 67).”
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L (2007, background): “Mitochondrial fusion plays an important role in controlling the shape and function of mitochondria (Okamoto and Shaw, 2005; Chan, 2006).”