Functions and dysfunctions of mitochondrial dynamics

By Scott A. Detmer, D. C. Chan. Nature reviews. Molecular cell biology, 2007

1,389 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/abe36cc9c70b6c05058adf348e4ac4eb0638c725

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Citations in the corpus

Cancer as a metabolic disease (2010, background): “Considering the dynamic behavior of mitochondria involving regular fusions and fissions [86], abnormalities in mitochondrial lipid composition and especially of cardiolipin could be rapidly disseminated throughout the cellular mitochondrial network and could even be passed along to daughter cells so”
Dynamin, a membrane remodelling GTPase (2012, background): “The two intracellular fission reactions besides endocytosis that clearly require DLPs are the fission of mitochondri”
Mitochondrial fusion and fission in cell life and death (2010, background): “Research on mitochondrial fusion and fission (collectively termed mitochondrial dynamics) gained much attention in recent years, as it is important for our understanding of many biological processes, including the maintenance of mitochondrial functions, apoptosis and agein”
Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2013, neutral): “Mitochondria are highly dynamic organelles that undergo continual ﬁ ssionandfusioneventswhichregulatethemorphologyanddistribution of mitochondria [113].”
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations (2010, neutral): “INTRODUCTION Mitochondrial fusion and fission have emerged as important processes that govern mitochondrial function from yeast to mammals (Detmer and Chan, 2007a; Suen et al., 2008; Okamoto and Shaw, 2005; Hoppins et al., 2007).”
Mitochondrial fragmentation in neurodegeneration (2008, background): “Regulation of fission and fusion Cells continually adjust the rate of mitochondrial fission and fusion in response to changing energy demands and to facilitate the distribution of mitochondri”
Mitochondria in innate immune responses (2011, background): “Mitochondrial dynamics determine the integrity of the mitochondrial network and maintain respiratory capacity, but also participate in several other processes, including mammalian development, neurodegeneration and apoptosi”
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases (2009, background): “In the past decade, our view of mitochondrial dynamics has expanded from a curious phenomenon into an integral cell biological process influencing many cellular functions and ultimately survival (1,2).”
The role of mitochondria in apoptosis. (2008, background): “The mitochondrial reticulum can be rapidly remodeled by dynamic fission and fusion events in response to the physiological requirements of a cell (1, 66, 67).”
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, neutral): “41 – 43 It endows mitochondria with different shapes accompanied by changes in quantity and quality of mitochondria, thus ﬁ nally affecting cell metabolism and function.”
Classification of low quality cells from single-cell RNA-seq data (2016, background): “There is an extensive literature on the relationship between mtDNA, mitochondrially localized proteins, and cell death [34, 35].”
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “Recent work has highlighted the importance of mitochondrial fusion and fission in cellular function and animal physiology (13, 41).”