OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.

By C. Frezza, S. Cipolat, Olga Martins de Brito, Massimo Micaroni, Galina V. Beznoussenko, Tomasz Rudka, Davide Bartoli, Roman S. Polishuck, N. Danial, Bart De Strooper and 1 more. Cell, 2006

1,669 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/feb58e55bcee08365beb73c187236c506b0c69f5

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Citations in the corpus

Mitochondrial membrane permeabilization in cell death. (2007, neutral): “Moreover, recent work suggests that the junctions between ICS and IMS are maintained by Opa1 (optic atrophia 1) (226), an integral protein of the IM with established roles in mitochondrial dynamics (113, 605).”
Mitochondrial Cristae: Where Beauty Meets Functionality. (2016, positive): “Among them, [4_TD$DIFF]OPA1 and the MICOS complex are the masters of cristae dynamics [10,27].”
Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency (2013, positive): “For protein crosslinking, mitochondria treated as indicated were incubated with 1 mM 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) or 1 mM bismaleimidohexane (BMH), as previously described (Frezza et al., 2006).”
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. (2009, positive): “Consistent with previous reports using RNAi knockdown (Olichon et al., 2003; Griparic et al., 2004; Frezza et al., 2006), we found that OPA1-null cells had severe ultrastructural defects in the mitochondria, including swollen mitochondria and defects in cristae organization, such as concentric…”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, positive): “…mitochondrial fragmentation is suppressed by knockdown of either Drp1 or Mff but not hFis1 Opa1 knockdown causes extensive mitochondrial fragmentation and cristae disorganization with increased sensitivity to apoptotic stimuli (Olichon et al., 2003; Lee et al., 2004; Frezza et al., 2006).”
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability (2011, neutral): “Whereas OPA1 and cristae organization are directly linke”
Mitochondrial fragmentation in neurodegeneration (2008, neutral): “Studies have identified several proteases that might cleave OPA1, including PARL”
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L (2007, positive): “OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics (Olichon et al., 2003; Frezza et al., 2006).”
Mitochondria and cell death: outer membrane permeabilization and beyond (2010, positive): “Two IMS proteins, optic atrophy protein 1 ( OPA1 ; a dynamin-like GTPase) and presenilins-associated rhomboid-like protein ( PARL ; a rhomboid protease) have been found to regulate cristae remodelling during apoptosi”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, positive): “In addition, OPA1, through the formation of oligomers, has a function in the formation of the cristae junction (Frezza et al , 2006).”