Suppression of allergic airway inflammation by helminth-induced regulatory T cells
By M. Wilson, Matthew D Taylor, A. Balic, C. Finney, J. Lamb, Rick M. Maizels. Journal of Experimental Medicine, 2005
666 citations recorded by the source corpus.
Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections. Epidemiological studies, however, indicate that Th2 cell–stimulating helminth parasites may also counteract allergies, possibly by generating regulatory T cells which suppress both Th1 and Th2 arms of immunity. We therefore tested the ability of the Th2 cell–inducing gastrointestinal nematode Heligmosomoides polygyrus to influence experimentally induced airway allergy to ovalbumin and the house dust mite allergen Der p 1. Inflammatory cell infiltrates in the lung were suppressed in infected mice compared with uninfected controls. Suppression was reversed in mice treated with antibodies to CD25. Most notably, suppression was transferable with mesenteric lymph node cells (MLNC) from infected animals to uninfected sensitized mice, demonstrating that the effector phase was targeted. MLNC from infected animals contained elevated numbers of CD4+CD25+Foxp3+ T cells, higher TGF-β expression, and produced strong interleukin (IL)-10 responses to parasite antigen. However, MLNC from IL-10–deficient animals transferred suppression to sensitized hosts, indicating that IL-10 is not the primary modulator of the allergic response. Suppression was associated with CD4+ T cells from MLNC, with the CD4+CD25+ marker defining the most active population. These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo.
Subfields: Immunology, Parasitology, Physiology
View Paper: https://www.semanticscholar.org/paper/8393fba634164f58b201fa5cf3adc5642bb960b9
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Citations in the corpus
- Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. (2007, background): “Helminthic infections that intensely induce TH2 cytokines and IgE synthesis protect IgE-sensitized infants from atopic diseases.(30,31) Likewise, probiotics seem not to affect sensitization per se but regulate the path from sensitization to clinical disease, thus, as this study shows, increasing the”
- The Foxp3+ regulatory T cell: a jack of all trades, master of regulation (2008, background): “However, in some other situations, the source of these suppressive cytokines is not limited to T reg cell”
- Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity (2009, background): “Moreover, helminth infection is associated with iminished reactivity to bystander allergens and autoantigens, both n model systems [8,14] and in human studies [15,16].”
- Toll-like receptor function and signaling. (2006, background): “Regulatory T-cell generation, rather than TH2-to-TH1 shift, is possibly involved in alleviating allergic inflammation.(28)”
- Regulatory T cells and infection: a dangerous necessity (2007, background): “For example, during gastrointestinal infection, the helminth-driven natural T Reg -cell suppression of the function of effector cells is responsible for protection against subsequent airway inflammatio”