Dectin-1: a signalling non-TLR pattern-recognition receptor

By Gordon D. Brown. Nature reviews. Immunology, 2006

1,165 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ad5f469577a4d707eb77046877419cf1d1b7e9d5

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In Immunology

Citations in the corpus

Alternative activation of macrophages: mechanism and functions. (2010, background): “Pathogens such as Aspergillus and Candida utilize TLR-2 and TLR-6 and the beta glucan receptor Dectin-1 to infect macrophages (Brown, 2006).”
The effects of β-glucan on human immune and cancer cells (2009, background): “It then triggers effective immune responses including phagocytosis and proinflammatory factors production, leading to the elimination of infectious agents [34,35].”
Recognition of microorganisms and activation of the immune response (2007, background): “, being involved in the phagocytosis of fungal pathogens, the induction of an antimicrobial response (such as activation of NADPH oxidase) and the production of cytokine”
Soluble Dectin-1 as a tool to detect β-glucans (2006, background): “Dectin-1 is able to recognize several fungal species and contributes to the generation of the immune response to these organisms (Brown, 2006).”
History of lectins: from hemagglutinins to biological recognition molecules. (2004, background): “This signaling occurs cooperatively with Toll-like receptors (TLR) and the use of spleen tyrosine kinases (SYK) [31,32].”
Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Dectin-1 is the principal receptor for fungal β-glucans [207] and was proposed to participate in fungal recognition by neutrophils [202].”
Role of yeast cell wall polysaccharides in pig nutrition and health protection (2007, background): “Recently obtained data strongly support the assumption that (1→3)-β-D-glucans mediate their protective and immunopotentiating effect by binding to specific sites (receptors) on monocytes/macrophages and granulocytes triggering a cascade of immunological events (Brown 2006; Gantner et al. 2003; Herre”
Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, positive): “Dectin 1 recognizes β-1,3-glucans in a calcium-independent manner and is involved in both ligand uptake and phagocytosis, as well as the production of pro-inflammatory cytokine”