Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

By Yasush Onishi, Z. Fehérvári, Tomoyuki Yamaguchi, Shimon Sakaguchi. Proceedings of the National Academy of Sciences of the United States of America, 2008

748 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/5962cf9f9bfd4d144263e16d0b1cb1ae806b9c0c

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In Immunology

1. Shimon Sakaguchi
2. K. Wing
3. D. Sansom
4. L. Walker
5. P. Krammer
6. Angelika Schmidt
7. Nina Oberle
8. M. Miyara

Citations in the corpus

• Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, neutral): “One study (Pandiyan et al., 2007) has raised the possibility that Treg cells may compete with Foxp3 T cells for IL-2, consume it, and inhibit the proliferation of Foxp3 T cells, resulting in a form of apoptosis dependent on the proapoptotic factor Bim.”
• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “, 2000) was shown to be partly dependent on CTLA-4 and the adhesion molecule LFA-1, thereby indirectly inhibiting Tcon activation by APCs in vitro (Oderup et al., 2006; Onishi et al., 2008) and in vivo (Wing et al.”
• Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells (2013, background): “trol of T-cell function by Tregs and Teffs occurs through the ability of CTLA-4–positive cells to remove B7 ligands on antigen-presenting cells, thereby limiting their costimulatory potential (12, 13).”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “In addition, Treg cells are more mobile than naive T cells and can outcompete the latter by aggregating around DCs, thereby inhibiting the induction of effector T cells (213).”
• The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses (2011, methodology): “Using APCs rather than immobilized ICAM1, LFA1 was also shown to allow T Reg cells to compete with T cells for APC contact”
• Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “Further, FoxP3+ Treg cells out-compete naive T cells in in vitro aggregation around dendritic cells and downregulate their expression of CD80 and CD86 in a CTLA-4-dependent fashion (Onishi et al., 2008).”