T cell exhaustion

By E. Wherry. Nature Immunology, 2011

3,978 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7291276aa4ed81dac3df027ff162113a6ecf7333

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In Oncology

Citations in the corpus

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2016, positive): “However, this function can be hampered by tumor-mediated T cell exhaustion, such that T cells fail to activate cytotoxic effector functions (40).”
Gene expression markers of Tumor Infiltrating Leukocytes (2016, background): “The list also includes well-known markers for exhausted CD8 cells [12-14] and FOXP3 for Tregs.”
Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12 (2018, positive): “, 2008) but they can also be co-opted by tumors, which make them resist immune attack (Wherry, 2011).”
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells (2015, positive): “, 2011), and in CD8 T cells in the context of prolonged low-grade antigenic stimulation and/or inflammation, as encountered in chronic viral infections and cancer (Schietinger and Greenberg, 2014; Wherry, 2011).”
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. (2014, background): “We measured cell surface expression of differentiation markers CD62L, CD45RO, CD27, and CD57 (31), inhibitory receptors PD-1, LAG-3, TIM-3, and BTLA, typically expressed on chronically stimulated CD8+ T cells (23, 24, 32, 33), and costimulatory receptor 4-1BB (28, 34) and IL-2 receptor alpha CD25 (3”
The Principles of Engineering Immune Cells to Treat Cancer (2017, background): “Modulation of T Cell Exhaustion Under conditions of chronic antigen exposure and inflammation, T cells become functionally incapable of performing effector activities, a condition now termed T cell exhaustion (Wherry, 2011).”
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. (2016, background): “Because chronic infections are known to induce T-cell exhaustion through the expression of immune checkpoints such as PD1 [67], ICB’s administration could be responsible for an inflammatory reaction against such pathogen by reinvigorating the antipathogen immune response.”