The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1

By Y. Yoon, E. Krueger, B. Oswald, M. McNiven. Molecular and Cellular Biology, 2003

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View Paper: https://www.semanticscholar.org/paper/e98536066c4fc53de2b03b892816172dc48f90a7

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Citations in the corpus

Mitochondrial dynamics in mammalian health and disease. (2009, background): “Its pattern of localization, as shown by immunofluorescence, clearly differs from that of DRP1, as FIS1 signal is dispersed throughout the mitochondrial network (148, 285, 325).”
MiD49 and MiD51, new components of the mitochondrial fission machinery (2011, background): “Overexpression of Fis1 accelerates mitochondrial division, whereas its inactivation blocks fission, resulting in fused and elongated mitochondria (Yoon et al, 2003; Stojanovski et al, 2004).”
Mitochondrial dynamics and apoptosis. (2008, positive): “It remains to be determined if Drp1 directly binds Fis1, although cross-linking studies and fluorescence resonance energy transfer (FRET) techniques are consistent with this hypothesis (Yoon et al. 2003).”
Mitochondrial fusion and fission in mammals. (2006, background): “Extension of these studies into mammalian cells has identified dynamin-related protein 1 (Drp1) and Fis1 as components of the mammalian mitochondrial fission machinery (James et al. 2003, Smirnova et al. 2001, Yoon et al. 2003).”
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. (2006, background): “In mammals, fission is con- trolled by the dynamin-related protein DRP-1 (Smirnova et al., 2001) and its outer membrane (OM) adaptor hFis1 (James et al., 2003; Yoon et al., 2003).”
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy (2008, background): “…in mitochondrial autophagy was evaluated in INS1 cells expressing low levels of FIS1, the rate-limiting protein in the mitochondrial fission process (Yoon et al, 2003; Okamoto and Shaw, 2005) and in cells expressing a dominant-negative form of the fission protein DRP1 (DRP1K38A, or DRP1-DN).”
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, neutral): “…Laboratory, Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB4) and K.U. Leuven, Belgium 4Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA *Contact: luca.scorrano@unipd.it DOI 10.1016/j.cell.2006.06.025”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “The Mff gene encodes at least nine different splice variants, although their functional difference is not known (Gandre-Babbe The fundamental molecular mechanisms of mitochondrial fission seem to be conserved across species because the mammalian homologues of yeast Fis1 (hFis1 for human homologues) ”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, neutral): “Expression of DRP1-K38A, a dominant-negative mutant of Drp1, resulted in mitochondrial elongation in Mfn1 (cid:2) / (cid:2) as well as in WT and Mfn2 (cid:2) / (cid:2) cells, but not in Mfn1/2 (cid:2) / (cid:2) or Opa1 (cid:2) / (cid:2) cells, conﬁrming the requirement of either Mfn 1 or 2 and OPA1 ”
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice (2009, background): “Most Drp1 is cytosolic and is recruited to the surface of mitochondria by proteins such as Fis1p/Fis1, Mdv1p, Caf4p, and Num1p (Mozdy et al., 2000; Tieu and Nunnari, 2000; Cerveny et al., 2001; James et al., 2003; Yoon et al., 2003: Griffin et al., 2005; Cerveny et al., 2007b).”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “Mitochondrial fission is regulated by dynamin-related protein 1 (DRP1) and fission protein 1.(127,128) These proteins are highly expressed in the heart.”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “Fission is mediated by dynamin-related protein 1 (Drp1) (7, 8) and its interaction with binding partners Fis1 and/or mitochondrial fission factor (Mff) (9, 10).”