Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

By G. Twig, Alvaro A. Elorza, A. Molina, H. Mohamed, J. Wikstrom, G. Walzer, L. Stiles, S. E. Haigh, Steve Katz, G. Las and 7 more. EMBO Journal, 2008

3,048 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5f18f725a9702531ce5f792b3862a775a7e9b205

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Citations in the corpus

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases (2009, background): “Studies in pancreatic b-cells and COS7 cells show that mitochondrial fission can yield uneven products, with one depolarized daughter mitochondrion and one hyperpolarized mitochondrion (27).”
The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “Through fission, damaged mitochondria are sequestered and then degraded through dynamin -1- like protein (Drp1) (Twig et al., 2008).”
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both (2010, methodology): “Mitochondrial fission, which occurs following mitochondrial depolarization, is thought to precede and possibly promote mitophagy, during basal mitochondrial turnover.(30) To test whether mitochondrial fission or another consequence of depolarization is required in conjunction with stable expression ”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Direct measurements of Dwm in INS1 cells and COS7 cells show that in the majority of the fission events one of the two daughter mitochondria will leave the fission event with some level of depolarization (Dwm difference > 5 mV) (110) (Fig.”
Mitochondrial dynamics and apoptosis. (2008, background): “2007) suggesting connections between mitochondrial fission and autophagy, as recently made with Drp1 inhibition (Twig et al. 2008).”
Autophagy and aging. (2011, background): “Improved Function of Mitochondria Reportedly, mitochondrial fission can occur in an asymmetric fashion, yielding one functional mitochondrion (that undergoes successive rounds of fusion and fission) and one dysfunctional one with a low membrane potential (DJm) that is targeted for autophagic destruc”
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells (2012, methodology): “(c) HeLa cells were transfected with (Flag)N-Fundc1(1-155)-C(Myc) or (Flag)N-Fundc1(1-139)C(Myc) vectors, respectively.”
The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “…to themodel that the fragmentation of mitochondria may facilitate their engulfment by autophagosomes (Buhlman et al., 2014; Tanaka et al., 2010; Twig et al., 2008) and fits with phenotypes of PINK1- and Parkinmutant flies that are reversed by promoting mitochondrial fission (Deng et al., 2008;…”
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. (2010, background): “obtained in yeast suggest that mitochondrial fission and fusion processes are important to segregate functional from non-functional regions followed by subsequent autophagic degradation of the nonfunctional parts [62].”
ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, positive): “that BNIP3 and NIX can trigger mitochondrial depolarization, and that mitochondrial depolarization is sufficient to cause mitophagy.(74,75) In support of this model, Sandoval et al.”
Mitochondrial Cristae: Where Beauty Meets Functionality. (2016, background): “Mitochondria can switch from an elongated and interconnected network to a fragmented state via fusion and fission events during the so-called ‘mitochondrial life cycle’ [1].”
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. (2008, background): “Co-staining with TMRE or OPA1 antibody revealed that non-fusing mitochondria are depolarized by ~7 mV compared to average Δψm and have approximately 50% less OPA1 compared to the rest of mitochondrial web [16].”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “Mitochondrial fragmentation and dysfunction have been described as preconditions for autophagy ofmitochondria (mitophagy) under different conditions (21, 27, 36), which led us to investigate whether starvation-induced mitochondrial fusion can prevent mitochondria from being targeted for autophagy.”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, positive): “…to fuse, through for example downregulation of ﬁssion proteins, led to opposite results, that is, decrease in membrane potential and ATP production, probably because unbalancing ﬁs-sion and fusion processes damage mitochondria (Rossignol et al , 2004; Parone et al , 2008; Twig et al , 2008).”
The mitophagy pathway and its implications in human diseases (2023, background): “159 However, mito-phagy decreases the number of mitochondria and thus the energy provided to the body.”