Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

By Angelika S. Rambold, B. Kostelecky, Natalie Elia, Jennifer Lippincott-Schwartz. Proceedings of the National Academy of Sciences of the United States of America, 2011

1,124 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ae6a10653108d6edefd752ba4589e6e91bf9d6e

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Citations in the corpus

Oxidative stress and autophagy: the clash between damage and metabolic needs (2014, background): “Recently, it has been proposed that under nutrient deprivation, mitochondria attempt to protect themselves from autophagic removal by promoting fusion and inhibiting fission events.(61,62) The combination of these two inputs results in mitochondrial elongation that further impedes organelle engulfme”
Mitochondria: In Sickness and in Health (2012, background): “Indeed, nutrient starvation in cultured cells induces the formation of a hyperfused mitochondrial network, which protects mitochondria from elimination via mitophagy (Gomes et al., 2011a; Rambold et al., 2011).”
The mitophagy pathway and its implications in human diseases (2023, background): “231 This suggests that the downregulated expression of Parkin may be a compensatory mechanism to prevent excessive mitophagy from clearing too many mitochondria.”
Metabolic regulation of mitochondrial dynamics (2016, background): “Negative regulation of Drp1 by phosphorylation at S637 also occurs during mTOR inhibition and nitrogen starvation, which increases cAMP levels and activates PKA (Gomes et al., 2011; Rambold et al., 2011).”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “Collectively, although mitophagy seems to play a role in development, more work is needed in the future to further support such a notion.”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “76 PKA, one of the kinases regulating phosphorylation at the Ser637, acts in a cAMP-dependent manner which is indirectly responsive to high and low changes in cAMP/ATP.”
Mitochondrial Cristae: Where Beauty Meets Functionality. (2016, background): “For example, activation of the recycling autophagy pathway triggers mitochondrial elongation [2,3], protecting mitochondria from degradation and promoting mitochondrial ATP production to increase the efficiency of energy conversion during nutrient deprivation [2].”
The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “This protection from autophagy by hyperfusion occurs physiologically during certain types of starvation-induced autophagy, in which a fused mitochondrial network protects mitochondria from degradation.(59) In summary, a shift in the balance ofmitochondrial dynamics towards increased fission and decr”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “…Requiring Increased ATP Synthesis Capacity The opposite condition to nutrient excess, starvation, causes an acute inhibition of mitochondrial fission, by inhibiting Drp1 recruitment to the mitochondria, and mitochondrial elongation due to unopposed fusion (Gomes et al., 2011; Rambold et al., 2011).”