IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

By K. Wolk, Ellen Witte, Elizabeth Wallace, W. Döcke, S. Kunz, K. Asadullah, H. Volk, W. Sterry, R. Sabat. European Journal of Immunology, 2006

978 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/e8d0c517d9041aa8cad17c4cbd3f4978929b6845

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. D. Cua
2. Frank O. Nestle
3. J. Krueger
4. T. Korn
5. E. Bettelli
6. M. Oukka
7. V. Kuchroo

In Immunology

1. D. Cua
2. V. Kuchroo
3. R. Flavell
4. F. Sallusto
5. T. Korn
6. M. Oukka
7. E. Bettelli
8. A. Lanzavecchia

Citations in the corpus

• Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. (2008, background): “In murine systems, IL-17 induces autocrine IL-22 production, which results in inflammation and thickening of the epidermis, and which may have an important role in psoriatic inflammation (Wolk et al., 2006; Zheng et al., 2007).”
• IL-17 and Th17 Cells. (2009, background): “Furthermore, IL-22 induces keratosis in mouse models of psoriasis and plays a role in human psoriasis as well (213).”
• RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota (2011, neutral): “, S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B”
• Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis (2009, positive): “These cells and the cytokines produced by these cells are found in increased levels within skin affected by psoriasis (Chan et al., 2006; Wolk et al., 2006; Wilson et al., 2007; Zaba et al., 2007; Kryczek et al., 2008; Lowes et al., 2008; Harper et al., 2009).”
• Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “In these cells, IL-22 triggers the production of antimicrobial peptides and expression of genes involved in cellular differentiation and survival and is therefore thought to be involved in early host defense against microbial pathogens and in the homeostasis of epitheli”
• Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis (2010, positive): “IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.(18) Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis ”
• Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007, background): “T H -17 cytokines induce antibacterial peptides IL-17A, IL-22 and IL-26 regulate immunity in various epithelial cell types by enhancing the expression of genes encoding proinflammatory cytokines and antimicrobial molecule”
• Interleukin-22: immunobiology and pathology (2015, background): “IL-22 can also induce the expression of extracellular matrix (ECM)-degrading enzymes matrix metalloproteinases (MMP)-1 and -3, which are required for epithelial migratory capacity during epithelial repair (280).”
• Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, background): “rodentium and is required for epithelial cell secretion of several classes of antimicrobial factors (Wolk et al., 2004; Wolk et al., 2006; Zheng et al., 2008).”