Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

By T. Duhen, R. Geiger, D. Jarrossay, A. Lanzavecchia, F. Sallusto. Nature Immunology, 2009

1,118 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/ab6372c7e7147c60ff56ecf141ed4ba45f7269ed

How researchers see this paper

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In Immunology

1. Rafi Ahmed
2. F. Sallusto
3. A. Lanzavecchia
4. K. Araki
5. D. Artis
6. H. Spits
7. A. Luster
8. M. V. D. van den Brink

Citations in the corpus

• Skin immune sentinels in health and disease (2009, background): “A subset of circulating T cells with skin-homing potential that produce IL-22 but not IL-17 or IFNγ (termed T H 22 cells) has been recently identifie”
• Th2 Cytokines and Atopic Dermatitis (2011, background): “Recent studies have also identified a unique subpopulation of CD4+ T cells in humans that express IL-22 and IL-13 along with skin homing chemokine receptors [67,68].”
• Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (2011, neutral): “However, the epidermal TCRgd population is absent in human skin, and although an alternative lymphocyte population is present (Duhen et al., 2009), to our knowledge AhR has not been reported as a susceptibility locus to date.”
• OMIP‐018: Chemokine receptor expression on human T helper cells (2013, background): “Eight chemokine receptors were chosen based upon previously published observations implicating their preferential expression on T helper type 1 (Th1), Th2, Th17, or Th22 cells, and their role in controlling lymphocyte migration to secondary lymphoid tissues, B cell follicles or non-lymphoid tissues,”
• From Vaccines to Memory and Back (2010, positive): “, 2008) and Th22 (Duhen et al., 2009; Trifari et al., 2009) cells, which may be involved in allergy and skin defense, respectively.”
• Interleukin-22: immunobiology and pathology (2015, background): “Human production of IL-22 by T cells has been identified in TH1, TH17 and TH22 cells; where it is estimated that approximately 33% of IL-22-producing CD4+ T cells in peripheral blood are TH1 cells (co-expressing IFNγ), 50% produce IL-22 alone (TH22), and 15% are TH17 cells also producing IL-17 (30).”
• Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis (2009, positive): “…questions, identification and quantification of human Th17, Th22, and Th1 cells by flow cytometric analyses has been described over the last several years (Acosta-Rodriguez et al., 2007; Annunziato et al., 2007; Wilson et al., 2007; Cosmi et al., 2008; Duhen et al., 2009; Trifari et al., 2009).”