Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.

By Naoko Satoh-Takayama, C. Vosshenrich, Sarah Lesjean-Pottier, S. Sawa, M. Lochner, F. Rattis, Jean-Jacques Mention, K. Thiam, N. Cerf‐Bensussan, O. Mandelboim and 2 more. Immunity, 2008

1,127 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology

View Paper: https://www.semanticscholar.org/paper/465d88640b0fe499177029547011f00e09d4e2ee

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In Immunology

1. D. Artis
2. M. V. D. van den Brink
3. A. Hanash
4. J. Dudakov
5. F. Powrie
6. yang-xin fu
7. A. Diefenbach
8. Eric Wu

Citations in the corpus

• Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis (2014, neutral): “The effector functions of RORγt+ ILC3, and the development and maturation of ILFs depend on commensal-driven signals (37, 40, 41).”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, positive): “Development and/or survival of intestinal and peripheral LTilike cells strictly required IL-7R signaling (Luther et al., 2003; Meier et al., 2007; Satoh-Takayama et al., 2010; Schmutz et al., 2009).”
• The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “Recently, studies have identified two types of NK cells that express the NK cell natural cytotoxicity receptor NKp46 in the gut mucosa.(33) One type of gut NKp46 cell closely resembles conventional NK cells; the other type differs from classical NK cells by its limited IFNc production and absence of”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “1+CD127−) with the expression of typical NK cell markers (including NKG2D, DX5, CD122, CD11b, and Ly49 family members) (201).”
• Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. (2013, neutral): “These cytokines are regulated by the intestinal microbiota (Ivanov et al., 2009; Satoh-Takayama et al., 2008).”
• Interleukin-22: immunobiology and pathology (2015, background): “The intestinal barrier regulated by IL-22 is dynamic, involving cross-talk between ILC3 and the intestinal microbiota (69).”