IL-17 and Th17 Cells.

By T. Korn, E. Bettelli, M. Oukka, V. Kuchroo. Annual Review of Immunology, 2009

5,105 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7f91c4420181ccad208ddeb625d09ff7510e62df

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Citations in the corpus

• B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells (2012, background): “, 2010), which have a pathogenic role in autoimmune disease (Korn et al., 2009).”
• Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “Subsequent work has shown that, with some possible variation, these pathways also seem to be working in the human immune system in similar ways, with IL-23 having a role in stimulating and maintaining, if perhaps not inducing, Th17 responses (Korn et al., 2009).”
• MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis (2009, background): “Interleukin 17 (IL-17)-producing T helper cells (T H -17 cells) have been identified as a distinct subset of effector helper T cells that are essential in clearing foreign pathogens and inducing tissue inflammation during autoimmune diseas”
• FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “The Th17 cell subset adds an additional layer to this complex system of immune regulation, identifying separable developmental programs and cytokine profiles associated with extracellular bacteria and fungi, chronic inflammatory disease, and autoimmunity (Korn et al., 2009).”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “For example, IL-23 receptors appear not to be expressed until after the naive cell has partially completed its differentiation to becoming a Th17 cell, and consequently IL-23 plays little part in the initial determination of Th17 differentiation (21, 41, 43).”
• Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells (2010, background): “A striking example is provided by retinoic acid receptor-related orphan receptor-γt ( RORγt ), an isoform of RORγ (also known as NR1F3) that arises from an alternative T cell-specific promoter and is required, in combination with other factors, for the differentiation of T H 17 cell”
• Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “Th17 cells characterized by the production of IL-17A and the expression of the transcription factor ROR-gt participate in the immune response to extracellular bacteria and fungi and also contribute to the pathology of several autoimmune disorders (Ivanov et al., 2006; Korn et al., 2009).”