Interleukin-22: immunobiology and pathology

By J. Dudakov, A. Hanash, M. V. D. van den Brink. Annual Review of Immunology, 2015

821 citations recorded by the source corpus.

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T-helper (Th)-17 cells, γδ T cells, NKT cells and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has rapidly evolved since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues including the intestines, lung, liver, kidney, thymus, pancreas and skin. IL-22 primarily targets non-hematopoietic epithelial and stromal cells where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we will assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/400ef6c69eeae02da59a3847f03580b72dd41029

Citations in the corpus

• Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration (2015, neutral): “Tissue-resident ILC3s are potent producers of IL-22 after damage, and expression of IL-22 is associated with reduced injury in colitis as well as several non-intestinal tissue damage models 3,4,6-9 .”
• Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, neutral): “Notably, IL-22 is strongly associated with tissue repair, particularly of lung and gut epithelial cells (Dudakov et al., 2015), suggesting that the SARS-CoV-2 CD4 T cell responsemay actively participate in lung tissue repair during COVID-19.”