Development, cytokine profile and function of human interleukin 17–producing helper T cells

By N. Wilson, K. Boniface, J. Chan, Brent S. McKenzie, W. Blumenschein, J. Mattson, Beth Basham, Kathleen M. Smith, Taiying Chen, F. Morel and 6 more. Nature Immunology, 2007

2,200 citations recorded by the source corpus.

Subfields: Dermatology, Immunology

View Paper: https://www.semanticscholar.org/paper/7b6366d15c34b37bc3786f703b560419943d2cf5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. Frank O. Nestle
2. Dan R. Littman
3. M. Suárez‐Fariñas
4. T. Korn
5. C. Dong
6. E. Bettelli
7. M. Oukka
8. V. Kuchroo

In Immunology

1. A. Jetten
2. Jinfang Zhu
3. W. E. Paul
4. Dan R. Littman
5. D. Cua
6. C. Dong
7. V. Kuchroo
8. Y. Belkaid

Citations in the corpus

• Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, background): “However, human T cells were originally shown to require IL-1 plus IL-23 or IL-6 to differentiate into Th17 cells and addition of TGF-b inhibits this polarization (AcostaRodriguez et al., 2007; Wilson et al., 2007).”
• Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, background): “In humans, IL-6, IL1-b, TGFb, and IL-23 have been proposed to induce the development of Th17 cells (Acosta-Rodriguez et al., 2007; Manel et al., 2008; Volpe et al., 2008; Wilson et al., 2007).”
• Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab (2011, background): “Human T H 17 cells express several pro-inflammatory cytokines, including IL-17A, IL-17F, IL-22, IL-26 and IFN-&gamma”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “In addition to the induction of RORγt, IL-17, and IL-17F, differentiation along the Th17 lineage is associated with increased expression of IL-21 and IL23R [Acosta-Rodriguez et al., 2007; Korn et al., 2007a; Laurence and O'Shea, 2007; Nurieva et al., 2007;Wilson et al., 2007; Zhou et al., 2007].”
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (2009, result): “These findings are consistent with the suggestions that IL-23 may be central to differentiation rather than expansion or survival of pathogenic Th17 cells (McGeachy and Cua, 2008; Wilson et al., 2007).”
• Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling (2010, positive): “These data thus shed light on previous contradictory data pertaining to mouse versus human Th17 differentiation and indicate that there may be no species-specific difference 22–24 .”
• Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…that produce IL-17 (Th17 cells) have been recognized as a distinct, highly proinflammatory T cell subset that may play an even more important role in inflammatory disease (Acosta-Rodriguez et al., 2007; Annunziato et al., 2007; Wilson et al., 2007; Tesmer et al., 2008; Damsker et al., 2010).”