Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis
By S. Kagami, Heather L. Rizzo, J. J. Lee, Y. Koguchi, A. Blauvelt. Journal of Investigative Dermatology, 2009
657 citations recorded by the source corpus.
Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals. CCR6 was the best cell surface marker for IL-17A+ cells when compared with IL-23R or CD161. CCR6+, IL-17A+, IL-22+, CCR6+ IL-17A+, CCR6+ IL-22+, CCR6+ tumor necrosis factor-α+, IL-17A + IFN-γ−, IL-17A + IL-22 + IFN-γ−, and IL-17A + IL-22−IFN-γ− cells were increased in psoriatics (all values P < 0.001), indicating elevations in circulating Th17 cells, using multiple criteria to define these cells. Th22 (IL-17A−IL-22 + IFN-γ−, P < 0.05) and Th1 (IL-17A−IFN-γ+, P < 0.05) cells were also increased in psoriatics, but to a lesser extent. Inhibition of either NF-κB or STAT3 in vitro blocked cytokine production by both Th17 and Th1 cells. Circulating levels of Th17 and Th1 cells decreased in a subset of five psoriasis patients serially evaluated following induction therapy with infliximab. In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis.
Subfields: Dermatology, Immunology
View Paper: https://www.semanticscholar.org/paper/3190a88eeba01a7f9b4512a0498dfd6083090f44
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Citations in the corpus
- Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. (2012, neutral): “Ustekinumab 5 (13) 6 (15) 2 (5) 6 (15) 4 (10) 18 (11)”
- Immunologic Effects of Vitamin D on Human Health and Disease (2020, background): “The hyperproliferation of keratinocytes is associated with TH1, TH17, and TH22 inflammatory response to self-antigen [81].”