Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

By D. Masopust, V. Vezys, A. Marzo, L. Lefrançois. Science, 2001

2,163 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dbbf14c7e796f95b87a009dbd636886df4b5c68c

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In Immunology

Citations in the corpus

Translating innate immunity into immunological memory: implications for vaccine development. (2006, neutral): “Although this concept was based on data generated in vitro, recent in vivo studies suggest that antigenspecific memory T cells persist in nonlymphoid compartments long after vaccination (Masopust et al., 2001), which suggests that memory cells are indeed capable of homing to such sites in vivo.”
Molecular and functional profiling of memory CD8 T cell differentiation. (2002, neutral): “subsets of memory CD8 T cells have re- In summary, several genes involved in signal transceived much attention, but it is not clear how these duction, cell migration, and cell division are differentially different subsets are generated ( Masopust et al., 2001; regulated in memory CD8 T cells as com”
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1 (2010, methodology): “Isolation of lymphocytes from the livers and lungs was carried out via an established protocol as described (Masopust et al., 2001).”
Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment (2003, background): “Several recent reports have demonstrated the presence of antigen-specific memory T cells in nonlymphoid tissues (46, 47, 62).”
Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1 (2002, methodology): “We extended this observation to extralymphoid tissues as we have previously demonstrated that virus-specific primary and memory CD8 T cells populate many nonlymphoid tissues (14).”
Human T cell development, localization, and function throughout life (2018, background): “…infection models of heterogeneous tissue distribution of memory T cells and distinct features of T cells in specific sites (Bingaman et al., 2005; Masopust et al., 2001; Masopust et al., 2004) suggested that circulating T cells in humans may not be representative of their counterparts in tissues.”
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells (2003, background): “, activation by antigen confers to T cells the ability to home to non-lymphoid site”
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets (2012, neutral): “CD45RO memory T cells are subdivided into two subsets: CCR7 ‘‘central memory’’ (Tcm) cells, which migrate to lymphoid tissue, and CCR7 ‘‘effector memory’’ (Tem) cells, which circulate to nonlymphoid sites (Masopust et al., 2001; Sallusto et al., 1999, 2004).”
From Vaccines to Memory and Back (2010, positive): “Recent studies have shown that repeated boosting can drive memory T cells towards terminal differentiation (Masopust et al., 2006; Wirth et al., 2010).”
The light and dark sides of intestinal intraepithelial lymphocytes (2011, neutral): “The intestinal tissue is particularly enriched for antigen-experienced cytotoxic CD8αβ + TCRαβ + T cell”
Quantifying memory CD8 T cells reveals regionalization of immunosurveillance (2015, background): “…CD8 T cells are broadly distributed throughout the host organism, but the overall magnitude and anatomic apportionment of this population remain unclear and controversial (Ganusov and De Boer, 2007; Masopust et al., 2001; Peaudecerf and Rocha, 2011; Reinhardt et al., 2001; Rocha et al., 1991).”