From Vaccines to Memory and Back

By F. Sallusto, A. Lanzavecchia, K. Araki, Rafi Ahmed. Immunity, 2010

650 citations recorded by the source corpus.

Summary Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently new methods have been developed to dissect the immune response in experimental animals and humans which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells – a journey from vaccines to memory and back.

Subfields: Epidemiology, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/57d54e94f79780ddd0710151aeadab114d63ae29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. F. Sallusto
2. Rafi Ahmed
3. F. Krammer
4. A. Lanzavecchia
5. J. Schenkel
6. D. Masopust

In Immunology

1. Rafi Ahmed
2. Bali Pulendran
3. F. Sallusto
4. A. Lanzavecchia
5. N. Restifo
6. J. Schenkel
7. Alessandro Sette
8. Mario Roederer

In Infectious Diseases

1. Alessandro Sette
2. Shane Crotty
3. Mario Roederer
4. Daniel C. Douek
5. Rafi Ahmed
6. Bali Pulendran
7. F. Krammer

Citations in the corpus

• A human memory T-cell subset with stem cell-like properties (2011, methodology): “Heterologous prime-boost approaches have been used to increase the frequency of memory T cells, but they have the undesired effect of driving T cells toward a state of terminal differentiatio”
• Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals (2020, positive): “Based on data from SARS patients in 2003–2004 (caused by SARS-CoV, the most closely related human betacoronavirus to SARS-CoV-2), and based on the fact that most acute viral infections result in development of protective immunity (Sallusto et al., 2010), a likely possibility has been that substantia”
• Immunological mechanisms of vaccination (2011, background): “In addition, differentiating memory CD4 + and CD8 + T cells can be subcategorized into central memory and effector memory cell subsets, each with a distinct functionalit”
• Tissue-Resident Memory T Cells (2014, background): “…productively primed within SLOs, they give rise to effector cells that migrate throughout the host and leave behind a memory population that persists long after pathogen clearance (Dutton et al., 1998; Harty and Badovinac, 2008; Lefrançois, 2006; Sallusto et al., 2010; Williams and Bevan, 2007).”
• L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “Cell 167, 829–842, Octo This is an open access article under the CC BY-N long-term protection (Kaech and Cui, 2012; Sallusto et al., 2010).”