The light and dark sides of intestinal intraepithelial lymphocytes

By Hilde Cheroutre, F. Lambolez, D. Mucida. Nature reviews. Immunology, 2011

643 citations recorded by the source corpus.

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form one of the main branches of the immune system. As IELs are located at this critical interface between the core of the body and the outside environment, they must balance protective immunity with an ability to safeguard the integrity of the epithelial barrier: failure to do so would compromise homeostasis of the organism. In this Review, we address how the unique development and functions of intestinal IELs allow them to achieve this balance.

Subfields: Immunology

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In Immunology

1. M. Colonna
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3. S. Gilfillan
4. Shizuo Akira

Citations in the corpus

• Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, positive): “NKp44+CD103+ ILC1 Have an Intraepithelial Location CD103 promotes the interaction of lymphocytes with epithelial cells by binding E-cadherin (Cepek et al., 1994) and is a marker of intraepithelial T lymphocytes (Cheroutre et al., 2011; Sheridan and Lefrançois, 2010).”