Human T cell development, localization, and function throughout life
By Brahma V. Kumar, T. Connors, D. Farber. Immunity, 2018
1,072 citations recorded by the source corpus.
SUMMARY T cells coordinate multiple aspects of adaptive immunity throughout life, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited timeframe, while in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight that tissue localization and subset delineation are key determinants of the T cell functional role in immune responses. We also discuss how anatomic compartments undergo distinct age-associated changes in T cell subset composition and function over a lifetime. Considering age and tissue influences on human T cells is important for developing targeted strategies to modulate T cell-mediated immunity in vaccines and immunotherapies.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/3a14b53e763378c61d939aec4e436c9a6d47b9c7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
Citations in the corpus
- Cross-tissue immune cell analysis reveals tissue-specific features in humans (2022, background): “This may be a resident population more prevalent in lymphoid sites (16).”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Interaction between CAFs and T lymphocytes T lymphocytes play a key role in modulating the adaptive immune response, and they comprise different subpopulations, such as Treg cells, helper T (Th) cells and cytotoxic T lymphocytes (CTLs) [206].”