Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
By Taheri Sathaliyawala, Masaru Kubota, N. Yudanin, D. Turner, Philip Camp, Joseph J. C. Thome, K. Bickham, H. Lerner, M. Goldstein, M. Sykes and 2 more. Immunity, 2012
809 citations recorded by the source corpus.
SUMMARY Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector and memory subsets conserved between diverse individuals. Effector-memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central-memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naïve subsets in lymphoid tissues and IFN-γ-producing effector-memory CD8+ T cells in mucosal sites. The T cell activation marker, CD69, was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/358c1aac399c02aadda078fad5de7404f5dd375f
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In Immunology
Citations in the corpus
- Tissue-Resident Memory T Cells (2014, background): “In this regard, it will be crucial to determine whether the total number of Trm cells established within NLTs is tightly regulated, as it appears to be for Tcm cells within LNs, or whether it is flexible, as shown for Tem cells (Vezys et al., 2009).”
- Human T cell development, localization, and function throughout life (2018, background): “Analysis of T cell subsets in tissues over six decades of adult life revealed that Tem cells were the predominant population in lungs, small and large intestines, spleen, and blood, and 30–50% of the LN T cell complement, while naïve T cells were primarily found in blood, spleen, and LN (Sathaliyawa”
- Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, methodology): “Spleen, lung, and intestinal samples were processed using enzymatic and mechanical digestion, resulting in high yields of live leukocytes, as described previously (Sathaliyawala et al., 2013; Thome et al., 2014).”