Molecular and functional profiling of memory CD8 T cell differentiation.

By S. Kaech, S. Hemby, E. Kersh, Rafi Ahmed. Cell, 2002

1,075 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e0e03d247227787d1d47c0bbb2be842254e8baa2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Shaping and reshaping CD8+ T-cell memory (2008, neutral): “Interestingly, this time frame is consistent with evidence that global gene expression patterns in memory CD8 + T-cell populations appear to stabilize around 40 days post infectio”
Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “cells and secrete antiviral cytokines in response to antigenic stimulation (9, 25, 47, 58, 60, 88, 130).”
Tolerance and Exhaustion: Defining Mechanisms of T cell Dysfunction (2013, neutral): “has revealed that naïve, effector and memory T cell differentiation states each have unique gene signatures that dictate their functional and phenotypic properties [1,2].”
Death by a thousand cuts: granzyme pathways of programmed cell death. (2008, background): “Mouse memory CTLs express abundant GzmB mRNA but no protein (50).”
Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, background): “ferent memory populations seem to form from a relatively uniform population of acutely expanded effector cells (50).”
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, methodology): “described (Kaech et al., 2002; Sarkar et al., 2008).”
Coregulation of CD8+ T cell exhaustion during chronic viral infection by multiple inhibitory receptors (2008, background): “After infection with Arm, virus-specific CD8 + T cells followed a typical pattern of functional memory CD8 + T cell differentiatio”
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function (2003, background): “Indeed, memory CD8 T cells were recently found to contain constitutive mRNAs for IFN- and the chemokine RANTES (26, 27), suggesting that a similar mechanism may contribute to the rapid memory response of adaptive immune cells.”
Signals required for programming effector and memory development by CD8+ T cells (2006, background): “Similarly, Ahmed’s group (46) has shown that CD8 T cells responding to LCMV are defective in MAPK upregulation by day 8, and the administration of IL-2 at this time leads to the maintenance of higher numbers of cells (50).”
Helping the CD8+ T-cell response (2004, background): “For this final differentiation step to occur, antigen must be cleared from the syste”
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells (2003, background): “These studies have shown that memory cell precursors exist in the effector cell population at the peak of the CD8 T cell response (day 8 after LCMV infection), but at that time they do not show the functional hallmarks of memory T cells found 1–2 months after infectio”
Lineage relationship and protective immunity of memory CD8 T cell subsets (2003, result): “Our recent data analyzing global gene expression patterns during memory T cell development are consistent with this model of progressive differentiatio”
From Vaccines to Memory and Back (2010, neutral): “Particularly valuable have been studies that have performed an integrative genomic analysis of antigen specific T cells as they progress from the naïve to effector to memory transition (Kaech et al., 2002).”