Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
By Xinyuan Zhou, Shuyang Yu, Dong-mei Zhao, J. Harty, V. Badovinac, Hai-hui Xue. Immunity, 2010
677 citations recorded by the source corpus.
T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD8+ T cell responses are unknown. Here we showed that TCF-1 deficiency limited proliferation of CD8+ effector T cells and impaired their differentiation towards a central memory phenotype. Moreover, TCF-1-deficient memory CD8+ T cells were progressively lost over time, exhibiting reduced expression of the anti-apoptotic molecule Bcl-2, interleukin-2 receptor β chain and diminished IL-15-driven proliferation. TCF-1 was directly associated with the Eomes allele and the Wnt-TCF-1 pathway was necessary and sufficient for optimal Eomes expression in naïve and memory CD8+ T cells. Importantly, forced expression of Eomes partly protected TCF-1-deficient memory CD8+ T cells from time-dependent attrition. Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/0a0c2bf6671659a12a2975b6a0334625eb43fae8
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Citations in the corpus
- Defining T cell states associated with response to checkpoint immunotherapy in melanoma (2018, positive): “(legend continued on next page) 1002 Cell 175, 998–1013, November 1, 2018 self-renewal, and persistence of memory CD8+ T cells (Zhou et al., 2010) and reinvigoration and effective immunity of CD8+ T cells against chronic lymphocytic choriomeningitis mouse virus (LCMV) infection upon anti-PD-1…”
- Acquired Resistance to Immune Checkpoint Inhibitors (2020, background): “…and shown to reinvigorate and sustain effective immunity of CD8+ T cells against chronic lymphocytic choriomeningitis mouse virus (LCMV) infection upon anti-PD-1 treatment (Blank et al., 2019; Chen et al., 2019b; Hudson et al., 2019; Im et al., 2016; Utzschneider et al., 2016; Zhou et al., 2010).”
- CD8+ T Cells: Foot Soldiers of the Immune System (2011, positive): “Runx3, Notch2, and the canonical Wnt pathway effector, Tcf-1, are all involved in CD8 + effector T cell differentiation (Cruz-Guilloty et al., 2009; Jeannet et al., 2010; Maekawa et al., 2008; Zhou et al., 2010).”
- Metabolic Instruction of Immunity (2017, positive): “…2012), augmenting glycolysis genetically via VHL deletion favors the formation of effector memory T cells instead, which have low levels of TCF-1, a transcription factor that is expressed in stable populations of central memory T cells capable of self-renewal (Phan et al., 2016; Zhou et al., 2010).”
- A human memory T-cell subset with stem cell-like properties (2011, background): “Considering the emerging role of TCF–β-catenin signaling in the formation and maintenance of memory T cell”
- T Cell Dysfunction in Cancer (2018, background): “…for memory formation following acute infection, but is also expressed by the terminally exhausted T cell pool in chronic infection, contributing to the upregulation of inhibitory receptors seen in these cells (Banerjee et al., 2010; Intlekofer et al., 2005; Paley et al., 2012; Zhou et al., 2010).”