Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1

By K. Schluns, K. Williams, A. Ma, Xincheng Zheng, L. Lefrançois. Journal of Immunology, 2002

609 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/e24d11e5099ede0511ba6a16a637519c6a39d6e4

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In Epidemiology

1. E. Wherry
2. Edward J. Pearce
3. Rafi Ahmed
4. Erika L. Pearce
5. S. Kaech

In Immunology

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Citations in the corpus

• Heterologous immunity provides a potent barrier to transplantation tolerance. (2003, background): “The putative mechanism of action of DSG is to inhibit translocation of NF-κB, a transcription factor involved in many cellular processes, including T cell activation (41).”
• The mTOR kinase determines effector versus memory cell fate of CD8+ T cells by regulating T-bet and Eomesodermin expression (2010, background): “, 2000), CD122 (IL-15Rb and essential for memory CD8 T cell homeostatic renewal) (Schluns et al., 2002), KLRG1 (inversely corelated with memory CD8 T cell generation) (Joshi et al.”
• Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development (2011, background): “…cytokines IL-2 and IL-15, which are critical for the development and maintenance of CD8+ Teff cells and memory T cells, respectively (Kennedy et al., 2000; Mitchell et al., 2010; Sandau et al., 2010; Schluns et al., 2002; Surh and Sprent, 2008; Tan et al., 2002; Zhang et al., 1998), influence SRC.”
• Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “The cytokines IL-7 and IL-15 are primarily responsible for this homeostatic turnover of memory CD8 T cells (14, 41, 64, 100, 101, 109).”
• Interleukin 12: still a promising candidate for tumor immunotherapy? (2014, background): “It also induces proliferation of naı̈ve CD8 and memory CD4 and CD8 T cells [13,52], promoting development of the primary response of effector CD8 T cells [52,72], and makes both CD4 and CD8 T cells resistant to the action of Treg cells [23].”