TRP channels as cellular sensors

By D. Clapham. Nature, 2003

2,767 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/c4c93c5c4d1689546834bc649d817a6cee3c03fb

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In Cellular and Molecular Neuroscience

In Nutrition and Dietetics

In Sensory Systems

Citations in the corpus

Transient receptor potential channels: targeting pain at the source (2009, background): “These nociceptive ion channels, which essentially define the characteristic functional properties of nociceptors, are selectively or mainly expressed in these neuron”
STIM1, an essential and conserved component of store-operated Ca2+ channel function (2005, background): “The role of TRP-family proteins as molecular candidates for the CRAC channel has been widely discussed (Clapham, 2003; Montell, 2003).”
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, neutral): “In this regard, significant attention has focused on members of the TRP family of cation channels that serve as receptors for a variety of natural plant products that robustly excite nociceptors to elicit pain and inflammation ( Clapham, 2003; Wang and Woolf, 2005).”
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. (2004, methodology): “The hyperalgesia could be mediated by the release of neuropeptides such as substance P and CGRP upon plex variables, including the type of heterologous expression systems used (Clapham 2003).”
An introduction to TRP channels. (2006, background): “Each subfamily contains at least one vertebrate representative; mammals bear representatives from all subfamilies except TRPN (5, 6).”
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function (2005, background): “TRPCs form homo- and heterotetramers that can interact with a variety of other protein”
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors (2005, background): “The principal candidates for mammalian thermoreceptors have been categorized into the transient receptor potential (TRP) family of nonselective cation channels (Clapham, 2003; Moran et al., 2004).”
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 (2004, background): “TRPV1 belongs to the greater family of TRP (transient receptor potential) channels, many of which are key components of signal transduction pathways in a variety of sensory system”
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells (2004, background): “Moreover, TRP channels are found in a variety of sense organs, probably mediating pheromone transduction (TRPC2), sweet and bitter taste (TRPM5), warm and cool thermal sensation (TRPV1–4, TRPM8, TRPA1), insect vision (TRP, TRPL, TRPL-γ), insect touch (NOMPC), and insect hearing (Nanchung”
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, neutral): “, 1999), TRPA1 (or ANKTM1) is similar to other TRP channels in having six putative transmembrane domains with a putative pore-forming helix between the fifth and sixth transmembrane domains (Clapham, 2003).”
TRPC1 forms the stretch-activated cation channel in vertebrate cells (2005, background): “Most recently, attention has focused on the idea that the TRP channels act as cellular sensors (reviewed in ref”
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration (2008, background): “The Drosophila melanogaster transient receptor potential protein (TRP) and its homologs are polypeptide subunits that assemble into tetramers to form cation channels activated by sensing diverse stimuli from the extracellular environment and from inside the cel”