TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

By Shinichiro Yamamoto, S. Shimizu, Shigeki Kiyonaka, N. Takahashi, Teruaki Wajima, Y. Hara, T. Negoro, T. Hiroi, Y. Kiuchi, T. Okada and 7 more. Nature Medicine, 2008

612 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/22f715105723669b09ef391aca53a89bfeacefd2

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In Immunology

1. Oliver Soehnlein
2. L. Lindbom
3. Nikolaos G. Frangogiannis
4. P. Kubes

Citations in the corpus

• TRP Channels (2012, neutral): “This notion was further supported by the Trpm2 knockout mouse, in which H2O2-induced Ca2+-influx and chemokine production in monocytes, neutrophil infiltration, and ulceration were impaired (495).”
• Phagocyte partnership during the onset and resolution of inflammation (2010, background): “The induction of chemokine synthesis is not, however, restricted to receptor ligation, as indicated by chemokine production by macrophages following exposure to reactive oxygen species (ROS”