Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors

By Kimiko Kobayashi, T. Fukuoka, K. Obata, H. Yamanaka, Yi Dai, A. Tokunaga, K. Noguchi. The Journal of comparative neurology, 2005

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Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Beyond peripheral sensory neurons (477), the TRPM8 channel has been identified on the trigeminal (2) and dorsal root ganglia (431), indicating a functional relevance in migraine.”
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, unknown): “TRPA1 is expressed in smalldiameter neurons of the trigeminal and dorsal root ganglia (DRGs), mostly in a subset of cells that express TRPV1 but not TRPM8 (Story et al., 2003; Bautista et al., 2005; Kobayashi et al., 2005).”
TRP channels and pain. (2013, background): “Indeed, within mammalian sensory ganglia, TRPA1 is expressed exclusively by peptidergic C-fibers (Bautista et al. 2005, Kobayashi et al. 2005), which, as described above, initiate neurogenic inflammation through the release of substance P, neurokinin A, and CGRP.”
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, background): “Indeed, this is consistent with more recent studies examining the expression of TRPA1 in trigeminal or dorsal root ganglia using histological methods (Bautista et al., 2005; Kobayashi et al., 2005; Nagata et al., 2005).”