TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

By David P. Corey, J. García-Añoveros, J. Holt, Kelvin Y. Kwan, Shuh-Yow Lin, M. Vollrath, A. Amalfitano, Eunice L M Cheung, B. Derfler, A. Duggan and 6 more. Nature, 2004

737 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/22fab32f19abf3265b025b5f48e7060e290642c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. B. Nilius
2. G. Owsianik
3. Ardem Patapoutian
4. Veena Viswanath
5. T. Voets
6. C. Kung
7. D. Julius

In Sensory Systems

1. B. Nilius
2. G. Owsianik
3. Ardem Patapoutian
4. T. Voets
5. Veena Viswanath
6. A. Dhaka
7. D. Clapham
8. C. Kung

Citations in the corpus

• Transient receptor potential cation channels in disease. (2007, background): “TRPA1 has been considered as a likely candidate for the elusive mechanically gated transduction channel necessary for the auditory response in mammals (82, 133).”
• A possible unifying principle for mechanosensation (2005, background): “Recently, Corey et al.83 showed that TRPA1 messenger RNA appears at the appropriate time during hair-cell development, and that TRPA1-expression knock-down curtails transduction in vivo.”
• Biomimetic survival hydrodynamics and flow sensing (2015, background): “…by the fact that each haircell consists of bundles of kinocilia, which move in near unison, hence allowing the magnification of the produced signal (Corey et al. 2004), Asadnia et al. (2013c) developed a sensor consisting of graded rows of bundled polydimethylsiloxane (PDMS) polymer pillars…”
• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, neutral): “TRPA1 has been proposed as a candidate mechanosensitive transduction channel in the vertebrate inner ear (Corey et al., 2004).”
• Cellular mechanotransduction: putting all the pieces together again (2006, background): “When sound vibrations induce stereocilia deflection, they specifically focus mechanical energy through these tensed tip-links, and induce opening of mechanically gated ion channels, such as the transient receptor potential (TRP) ion channel, TRPA1 (28), located near the point of insertion of the tip”
• Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing (2005, background): “TRPA1 as a pore-forming subunit of the hair cell transducer In a separate study, some of us have reported, using an antibody to the C terminus of TRPA1, an immunoreactivity to the cuticular plates and the mechanosensory stereocilia of hair cells (Corey et al., 2004).”
• An introduction to TRP channels. (2006, background): “But TRPA1 also exhibits unique properties: It has been tentatively identified as the elusive hearing transduction channel (169, 170).”
• TRP Channels (2012, neutral): “Expression of TRPA1 is mainly found in nociceptive neurons of the dorsal root (DRG), trigeminal (TG), and nodose ganglia (49, 91, 388), but has also been found in heart myocytes, gastrointestinal mucosa, brain, renal tubular cells, hepatocytes, pancreatic acinar cells, prostatic transitional epithel”
• Trp ion channels and temperature sensation. (2006, background): “TRPA1 has also been identified as a candidate for the mechanosensitive transduction channel in vertebrate hair cells (Corey et al. 2004).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, critical): “Despite strong evidence that TRPA1 mediates hair-cell mechanotransduction (Corey et al., 2004), mice lacking TRPA1 do not have any detectable vestibular or auditory defects.”