TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.

By Kelvin Y. Kwan, A. Allchorne, M. Vollrath, Adam P. Christensen, Duan-Sun Zhang, Clifford J. Woolf, David P. Corey. Neuron, 2006

1,298 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/a6074ded977b9fe447a614b7ae1e7c6660d244b8

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Citations in the corpus

TRPM8 is required for cold sensation in mice. (2007, neutral): “Mice respond to acetone application to the surface of the paw by shakes, lifts, and licks (Bautista et al., 2006; Kwan et al., 2006 ).”
Attenuated cold sensitivity in TRPM8 null mice. (2007, positive): “Deletion of TRPA1 gene further suggests the functional importance of the TRPA1 protein in the perception of noxious cold (Kwan et al., 2006) and a clear involvement in chemical nociceptive signaling (Bautista et al.”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “TRPA1 was initially characterized as a noxious cold receptor (600), and lately its role in mechanosensation has been suggested (333, 646).”
TRP channels and pain. (2013, background): “Pharmacological and genetic studies have shown that TRPA1 plays an essential role in the nociceptive response to these and other environmental irritants (Bautista et al. 2006, Bessac et al. 2009, Kwan et al. 2006, Macpherson et al. 2007b, McNamara et al. 2007).”
TRP Channels (2012, neutral): “The ﬁrst knockout studies conﬁrmed proposed role in chemical nociception, such as avoidance pain behavior induced by TRPA1 agonists such as MO acrolein (30,209), and further studies have shown the role .”
Mechanisms of sensory transduction in the skin (2007, result): “Two in vivo studies have provided some support for this idea by reporting deficits in acute cold transduction or inflammation/injury-induced cold hypersensitivity in Trpa1 −/− mic”
Transient receptor potential channels: targeting pain at the source (2009, background): “Two groups have independently shown that Trpa1 −/− mice have strong deficits in somatosensory chemosensatio”
Cellular and Molecular Mechanisms of Pain (2009, neutral): “Indeed, TRPA1deficient mice show dramatically reduced cellular and behavioral responses to all of these agents, as well as a reduction in tissue injury-evoked thermal and mechanical hypersensitivity (Bautista et al., 2006; Kwan et al., 2006).”