TRPC1 forms the stretch-activated cation channel in vertebrate cells

By R. Maroto, Albert Raso, T. Wood, A. Kurosky, B. Martinac, O. Hamill. Nature Cell Biology, 2005

634 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/8ff2afc5b4c139b77049e974776711d0b17e3966

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Citations in the corpus

Mechanisms of sensory transduction in the skin (2007, background): “For example, the canonical TRP channel TRPC1, which is activated by membrane stretch in Xenopus ooctye”
Mechanotransduction in vascular physiology and atherogenesis (2009, background): “Changes in membrane fluidity or tension could therefore trigger signalling through ion channels in cells under flo”
Cell mechanics: integrating cell responses to mechanical stimuli. (2007, background): “Transient receptor potential channel proteins have also been cited as possible mechanosensors (123); indeed, work in frog oocytes strongly indicates that TRCPC1 is a mechanosensitive cation channel (124).”
The multiple faces of caveolae (2007, background): “and the stretch-activated channel short transient receptor potential channel-1 ( TRPC1”
Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound (2008, background): “receptors, which is consistent with both channels possessing mechanosensitive properties [31,32] and being expressed in hippocampal neurons.”
TRP Channels (2012, neutral): “Overexpressed homomeric TRPC1 channels where reported to be activated by membrane stretch, PLC-coupled receptor activation or store depletion (189, 258, 518).”
Local force and geometry sensing regulate cell functions (2006, background): “Although clearly demonstrated for bacteria, it has not been shown whether either in-plane membrane tension or forces that are normal to the membrane are the primary cause of channel opening in animal cells, but most of the osmotic and other mechanosensitive responses require tethering to force-beari”
Cellular mechanotransduction: putting all the pieces together again (2006, background): “Mechanical distension of cell membranes, for example, using patch-clamp techniques, modulates the cation-transporting activity of stress-sensitive ion channels by producing conformational changes that alter their opening or closing rates through distortion of the associated lipid bilayer (3, 4) or t”
An introduction to TRP channels. (2006, background): “Evidence that TRPC1 also forms a stretch-activated channel was recently presented (42), suggesting that further heterogeneity in TRP channel function may remain to be discovered.”