Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

By S. Jordt, D. Bautista, H. Chuang, D. McKemy, P. Zygmunt, E. Högestätt, I. Meng, D. Julius. Nature, 2004

1,897 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Pharmacology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/9dd2e002731ed6e946ab01c1dddd4885024f3b7f

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In Nutrition and Dietetics

In Pharmacology

In Sensory Systems

Citations in the corpus

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing (2005, background): “4b) and others (Jordt et al., 2004) could not elicit cold activation of heterologously expressed TRPA1 channels.”
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors (2005, background): “Previous studies on the percentages of neurons expressing mRNAs for TrkA, TrkB, and TrkC reported quite variable results (35–45%, 7–33%, and 15– 43%, respectively) (Kashiba et al., 1995; Wright and Snider, 1995; Kashiba et al., 1996).”
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, neutral): “Only about 4% responded to a 5oC cold stimulus, but these were also menthol sensitive (Jordt et al., 2004).”
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels (2006, background): “TRPA1 is expressed in trigeminal ganglion neurons and is activated by several pungent compounds, including mustard oi”
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “5)], was first described in the article reporting the cloning of this channel (Jordt et al., 2004).”
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, positive): “, 2005, 2006) and mediates some responses to proinflammatory mediators, such as bradykinin (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2006).”
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, methodology): “Moreover, TRPA1 is always coexpressed with TRPV1, and our previous studies suggest that TRPA1 can be activated by increases in intracellular calcium (Jordt et al., 2004).”