Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

By M. Bandell, G. M. Story, S. Hwang, Veena Viswanath, S. R. Eid, Matt J. Petrus, Taryn J. Earley, Ardem Patapoutian. Neuron, 2004

1,815 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Complementary and alternative medicine, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/4afc4bf42130be5e2f58e6ed60f524801e2d82a4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Complementary and alternative medicine

In Sensory Systems

Citations in the corpus

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “Bradykinin-Induced Pain and Hyperalgesia Subcutaneous bradykinin causes inflammatory pain, and it has been proposed to activate TRPA1 via the B2R G protein-coupled receptor (Story et al., 2003).”
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. (2005, result): “We have previously shown that TRPA1 is expressed in a subset of TRPV1-positive neurons, and this is consistent with the capsacin- and cinnamaldehyde-response profiles (cinnamaldehyde activates a subset of capsaicin-responsive neurons) [17, 18].”
An introduction to TRP channels. (2006, background): “The active constituents of mustard oil (allyl isothionate) and garlic (allicin) robustly activate TRPA1 currents (166–168), and TRPA1 appears to be regulated by PLC-coupled receptors (168).”
Attenuated cold sensitivity in TRPM8 null mice. (2007, positive): “The thermoTRPs are also sensitive to chemical stimuli, such as capsaicin and mustard oil, that are known to produce a burning sensation through their ability to activate TRPV1 and TRPA1, respectively (Bandell et al., 2004; Caterina et al., 1997).”
Transient receptor potential cation channels in disease. (2007, background): “Some reports (31, 415) claim that TRPA1 can be activated by noxious cold ( 17°C), although such a mode of stimulation has been disputed by others (35, 189, 295).”
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “Indeed, TRPA1 resembles canonical receptor-operated TRP channels in that activation of the PLC pathway produces rapidly developing inward currents, even in the absence of other known stimuli.”
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, positive): “, 2005, 2006) and mediates some responses to proinflammatory mediators, such as bradykinin (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2006).”
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. (2006, background): “This has been demonstrated for endogenous molecules such as anandamide or bradykinin, for instance, both of which induce activation of the TRPV1 receptor (40).”
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing (2005, background): “…role in pain is also consistent with reports that TRPA1 is expressed by a larger percentage of neonatal rat trigeminal ganglia neurons (Jordt et al., 2004) and that it forms channels that gate in response to pungent chemicals, such as isothiocyanates (Bandell et al., 2004; Jordt et al., 2004).”
TFOS DEWS II pain and sensation report (2017, positive): “TRP cation channel subfamily A member 1 (TRPA1) is an extremely broadly tuned chemo-nocisensor channel [81,82].”
Mechanisms of sensory transduction in the skin (2007, background): “TRPA1 can be activated by a host of pungent chemicals containing allyl and reactive sulphur groups, such as those found in mustard oil or garlic, and by other irritants, such as acrolei”
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch (2011, positive): “Additionally, TRPA1 is activated downstream of G protein-coupled receptors, including the pro-algesic bradykinin receptor 18, 19 .”