TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

By D. Bautista, S. Jordt, T. Nikai, Pamela R. Tsuruda, Andrew J. Read, J. Poblete, E. Yamoah, A. Basbaum, D. Julius. Cell, 2006

1,911 citations recorded by the source corpus.

Subfields: Complementary and alternative medicine, Public Health, Environmental and Occupational Health, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/1b9efe30bd23af742f2f12fa2484c9b34c4362f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Complementary and alternative medicine

1. D. Julius
2. Clifford J. Woolf

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. B. Nilius
5. G. Owsianik
6. D. Bautista
7. A. Dhaka
8. A. Basbaum

Citations in the corpus

• Attenuated cold sensitivity in TRPM8 null mice. (2007, positive): “Since recent studies on TRPA1 knockout mice suggest that there can be gender differences in response to temperature (Bautista et al., 2006; Kwan et al., 2006), we tested both males and females for sensitivity to acetone-evoked cooling over a 28 day time course following CCI nerve injury.”
• Transient receptor potential cation channels in disease. (2007, background): “However, in a second independent study of a different trpa1 / ) mouse strain, altered cold and mechanosensitivity were not evident (35).”
• TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch (2011, positive): “In addition to being activated directly by endogenous and exogenous irritants, TRPA1 is a receptor-operated channel that can be activated by bradykinin, or other GPCR-coupled inflammatory mediators 29, 30 .”
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, result): “Because the TRPA1 channel is found in a subset of TRPV1 afferents (29), this result is consistent with our conclusion that TRPA1 is not required for acute cold-evoked pain behavior (30).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “The population of neurons for calcium imaging from adult DRG neurons in our study is different from the newborn trigeminal neurons used by Bautista et al. (2006) .”
• Mechanisms of sensory transduction in the skin (2007, background): “Second, in a separate study, dissociated sensory neurons from another Trpa1 -disrupted mouse line exhibited no discernable deficits in cold transduction, and the mice showed no differences in behavioural responses to cold temperature”
• TRP channels and pain. (2013, background): “In addition to being activated by PLC-evoked release of calcium from intracellular stores, TRPA1 may also amplify responses initiated by other calcium-permeable channels, such as TRPV1, further promoting sensitization to thermal or chemical stimuli (Bautista et al. 2006, 2012).”
• TRPM8 is required for cold sensation in mice. (2007, positive): “Mice respond to acetone application to the surface of the paw by shakes, lifts, and licks ( Bautista et al., 2006; Kwan et al., 2006).”
• Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, positive): “, 2005, 2006) and mediates some responses to proinflammatory mediators, such as bradykinin (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2006).”
• Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. (2017, positive): “such as 4-hydroxynonenal, prostaglandins and other lipid-derived metabolites (Bautista et al., 2006; Trevisani et al., 2007).”
• TRP Channels (2012, neutral): “The first knockout studies confirmed proposed role in chemical nociception, such as avoidance pain behavior induced by TRPA1 agonists such as MO acrolein (30,209), and further studies have shown the role .”