IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.

By M. Fort, J. Cheung, David C. Yen, Joan Li, S. Zurawski, S. Lo, S. Menon, T. Clifford, B. Hunte, R. Lesley and 6 more. Immunity, 2001

1,231 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/b96f3a3ef71c40e8be47e856dce3e4774b401112

How researchers see this paper

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In Immunology

1. D. Cua
2. V. Kuchroo
3. R. Locksley
4. TA Wynn
5. S. Gaffen
6. S. V. Van Dyken
7. T. Korn
8. M. Oukka

In Physiology

1. R. Locksley
2. TA Wynn
3. P. Barnes
4. A. Chawla
5. R. Reinhardt
6. Ari B. Molofsky
7. J. Nussbaum
8. Hong-Erh Liang

In Surgery

1. R. Locksley
2. Andrew N. J. McKenzie
3. P. Barnes
4. TA Wynn

Citations in the corpus

• The IL-17 family of cytokines in health and disease (2019, background): “Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.”
• IL-17 and Th17 Cells. (2009, background): “IL-25 induces the expression of Th2type cytokines and chemokines such as CCL5 (RANTES) and CCL11 (Eotaxin) and might be involved in Th2-type allergic responses (171).”
• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (2005, background): “Real-timePCRon 10ngof cDNA wasperformedas described before (Fort et al., 2001).”
• Interleukin‐13 in asthma pathogenesis (2004, background): “Overexpression of either IL-9 or IL-25 in the murine lung recapitulates much of the allergic phenotype (8, 9); however, the fact that neutralization of IL-13 in both of these situations completely abolishes the phenotype suggests that these two cytokines Wills-Karp IL-13 in asthma pathogenesis”
• Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion (2006, background): “Native IL-25 expression has been detected from in vitro–diff erentiated Th2 cells (13) and in vitro–cultured mast cells (14).”
• Th17: the third member of the effector T cell trilogy. (2007, background): “IL-25 (IL-17E) induces the expression of Th2 type cytokines and chemokines such as RANTES and Eotaxin-1 and plays a role in Th2-type allergic responses [3].”