The IL-17 family of cytokines in health and disease

By M. McGeachy, D. Cua, S. Gaffen. Immunity, 2019

1,260 citations recorded by the source corpus.

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25th anniversary of its discovery. While less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Over the past decade, however, it has become clear that the functions of IL-17 are far more nuanced than simply turning on inflammation. Accumulating evidence indicates that IL-17 has important context- and tissue-dependent roles in maintaining health during response to injury, physiological stress and infection. Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/ac9595c105d61927109ca0a3aaf531e8f062ad1c

Citations in the corpus

• SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “These functions vary according to the tissue in which IL-17 is expressed, being particularly important in the gastrointestinal tract and skin [159,160].”