Th17: the third member of the effector T cell trilogy.

By E. Bettelli, T. Korn, V. Kuchroo. Current Opinion in Immunology, 2007

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. (2009, background): “For example, cytokines within the inflammatory microenvironment play a critical role in promoting specific effector lineage commitment (Bettelli et al., 2007).”
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “CD4 Th cells play a critical role in orchestrating adaptive immune responses to various infections microbes [146, 147].”
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. (2009, background): “It is conceivable that IL-21, which was reported to play a role in Th17 cell development (Bettelli et al., 2007), although disputed (Coquet et al.”