Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
By P. Fallon, S. Ballantyne, Niamh E. Mangan, J. Barlow, A. Dasvarma, D. Hewett, Ann Mcilgorm, H. Jolin, Andrew N. J. McKenzie. Journal of Experimental Medicine, 2006
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Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy and asthma after inappropriate activation. We demonstrate that il25−/− mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells. We further establish a key role for interleukin (IL)-25 in regulating a novel population of IL-4–, IL-5–, IL-13–producing non–B/non–T (NBNT), c-kit+, FcɛR1− cells during helminth infection. A deficit in this population in il25−/− mice correlates with inefficient N. brasiliensis expulsion. In contrast, administration of recombinant IL-25 in vivo induces the appearance of NBNT, c-kit+, FcɛR1− cells and leads to rapid worm expulsion that is T and B cell independent, but type 2 cytokine dependent. We demonstrate that these IL-25–regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion.
Subfields: Immunology, Parasitology, Small Animals
View Paper: https://www.semanticscholar.org/paper/8448eb332ed530e44ddfa7d094673de767e65612
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In Immunology
In Parasitology
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Citations in the corpus
- Alternative activation of macrophages: mechanism and functions. (2010, background): “Role of AAMs in Infection, Fibrosis, and Immunopathology The generation and role of AAMs has been studied extensively in parasitic disease models (e.g., Anthony et al., 2006; Fallon et al., 2006; Hesse et al., 2001; Holscher et al., 2006; Reece et al., 2006), providing the best evidence for a regula”
- How are TH2-type immune responses initiated and amplified? (2010, background): “brasiliensis show delayed worm expulsion and induction of IL-5 and/or IL-13, whereas administration of IL-25 results in accelerated worm expulsion through the induction of T H 2-associated cytokines made by KIT + FceRI − NBNT cell”
- Protective immune mechanisms in helminth infection (2007, background): “The IL-17 -related cytokine IL-25 (also known as IL-17E) is also associated with the T H 2-type response and can promote T H 2-cell differentiation and nematode parasite expulsio”
- Systemically dispersed innate IL-13–expressing cells in type 2 immunity (2010, background): “As such, these resting cells resembled c-kit+ lineagenegative cells that were elicited in response to IL-25 or IL-33 in previous studies (6, 9, 12, 15, 16).”