Interleukin‐13 in asthma pathogenesis

By M. Wills-Karp. Immunological Reviews, 2004

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Innate lymphoid cells and asthma. (2014, neutral): “This reliance on IL-13 is similar to the situation observed in models of allergic asthma, although in patients with allergic asthma, the IL-13 is produced by allergen-specific TH2 cells and natural killer T (NKT) cells.(33) In another study influenza infection was shown to also activate ILC2s, but i”
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. (2012, background): “IL-13 is thought to mediate the effector phase of asthma by inducing airway remodeling and hyperresponsiveness as well as mucus hyperproduction (Wills-Karp, 2004).”
The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “Specifically, environmental factors drive a T helper cell type 2 (Th2)-biased immune response associated with strong production of cytokines such as IL-4, IL-5, and IL-13 which orchestrate the pulmonary inflammatory response, involving the recruitment and the activation of eosinophils, the productio”
Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury (2011, background): “IL-13 has a variety of effects that are relevant to asthma and Th2 inflammation, including the ability to induce IgE production (95), CD23 expression (96), mucus hypersecretion and goblet cell hyperplasia (85, 87, 90, 97), and endothelial P-selectin and vascular cell adhesion molecule-1 (VCAM-1) exp”