New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-251

By S. Hurst, T. Muchamuel, D. Gorman, J. Gilbert, T. Clifford, Sylvia Kwan, S. Menon, B. Seymour, Craig Jackson, T. Kung and 5 more. Journal of Immunology, 2002

645 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/b51adde973478a7619e5099665bb703a41fe20fb

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In Immunology

1. D. Cua
2. S. Gaffen
3. R. Locksley
4. C. Weaver
5. Y. Iwakura
6. M. McGeachy
7. S. V. Van Dyken
8. L. Harrington

In Physiology

1. R. Locksley
2. A. Chawla
3. R. Reinhardt
4. Wenjun Ouyang
5. Yan Zheng
6. J. Kolls
7. Ari B. Molofsky
8. J. Nussbaum

Citations in the corpus

• Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. (2005, background): “s Other members of the IL-17 family that have been t shown to induce neutrophilia are IL-17B and IL-17C, m which can bind IL-17RH1 (Hurst et al., 2002; Li et al., s 2000).”
• Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion (2006, background): “Interestingly, given the potent biological eff ects of IL-25, we have found that mRNA-encoding IL-25 is expressed at very low levels in the intestine as reported previously (30).”
• The IL-17 family of cytokines in health and disease (2019, background): “Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.”
• IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “Basophils, eosinophils, mast cells, and NKT cells are sources of IL-4 that may be important for Th2 differentiation (35–39), and each of these cell populations may be important for initiating Th2 responses to distinct pathogens or in distinct settings.”
• Systemically dispersed innate IL-13–expressing cells in type 2 immunity (2010, background): “IL-25 and IL-33 are expressed by epithelial cells, macrophages, and possibly other cell types (8), and they are expressed at elevated levels during infection with parasitic helminths (9, 10) or after challenge with allergens (9, 11).”
• The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. (2012, neutral): “Type 2 cytokine-producing ILCs were described by Rennick (Fort et al., 2001) and Coffman (Hurst et al., 2002).”
• Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009, background): “Overexpression of IL-17F or IL-17A in the lungs leads to increased proinflammatory cytokine and chemokine expression, resulting in inflammation associated with neutrophil infiltration (Hurst et al., 2002; Oda et al., 2005; Park et al., 2005; Yang et al., 2008).”