The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

By Jenny Mjösberg, J. Bernink, Korneliusz Golebski, J. Karrich, C. Peters, B. Blom, A. T. Te Velde, W. Fokkens, C. V. van Drunen, H. Spits. Immunity, 2012

624 citations recorded by the source corpus.

Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. Consistent with this, we report that the transcription factor GATA3 was highly expressed by human ILC2s. CRTH2(+) ILC2s were enriched in nasal polyps of patients with chronic rhinosinusitis, a typical type 2-mediated disease. Nasal polyp epithelial cells expressed TSLP, which enhanced STAT5 activation, GATA3 expression, and type 2 cytokine production in ILC2s. Ectopic expression of GATA3 in Lin(-)CD127(+)CRTH2(-) cells resulted in induction of CRTH2 and the capacity to produce high amounts of type 2 cytokines in response to TSLP plus IL-33. Hence, we identify GATA3, potently regulated by TSLP, as an essential transcription factor for the function of human ILC2s.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/6f0bb64e7121c26ad06ec910fa2914c4a657bb28

How researchers see this paper

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In Immunology

1. D. Artis
2. H. Spits
3. Andrew N. J. McKenzie
4. G. Eberl
5. A. Diefenbach
6. M. Colonna
7. M. V. D. van den Brink
8. A. Hanash

In Surgery

1. D. Artis
2. Andrew N. J. McKenzie
3. H. Spits
4. R. Locksley

Citations in the corpus

• Interleukin-22: immunobiology and pathology (2015, background): “In addition, GATA3 which is another factor involved at multiple stages of T cell development (113) and was originally thought to be only involved with ILC2 lineage development (101, 114, 115), also seems to play a crucial role in ILC3 differentiation (116).”
• Innate Lymphoid Cells: 10 Years On. (2018, positive): “ILC2s contain larger amounts of the transcription factor GATA3 than the other ILC subsets, and absence of GATA3 inhibits the development and function of these cells (Hoyler et al., 2012; Klein Wolterink et al., 2013; Furusawa et al., 2013; Mjösberg et al., 2012).”